SAS 6 COMPLETE Flashcards
What are the widely used substance in semisolids next to water?
Petrolatum and mineral oil
is a complex mixture of semisolids containing hydrocarbon aliphatic, cycle, saturated, unsaturated branch and unbranched substances in varying proportions.
Petrolatum
this is employed to increase the viscosity of mineral oil to prevent separation from the ointment
Hydrocarbon wax
example: paraffin and ceresin wax
are used in water removable creams as an emulsifier to develop a certain consistency in the cream.
stearic acid
are used in creams as auxiliary emulsifiers and emollients.
stearyl alcohol and cetyl alcohol
what are the 4 classes of semi-solid vehicles
Hydrocarbon vehicle
Absorption vehicle
water removable vehicle
water soluble vehicle
also known as greaseless ointment bases
water-soluble vehicle
____________ is the most commonly used in ointment vehicles.
Petrolatum
examples of absorption base
lanolin, cholesterol, sterols, sorbitan monostearate, monoolate
between water removable and absorption base which is w/o and o/w
w/o is absorption base whereas, o/w is water removable
anhydrous ointments are manufactured by this method.
Fusion method
this rectal suppository is intended to relief nausea, vomiting, and as tranquilizer
Prochlorperazine and Chlorpromazine
this rectal suppository is intended as opioid analgesia
morphine and oxymorphone
this rectal suppository is intended for anti-inflammatory analgesic and analgesic and antipyretic
Indomethacin
this rectal suppository relieves nausea and vomiting
Ondansetron
the majority of the components melt at rectal temperature of _______.
36 celsius
Most frequently employed suppository base
Oleaginous base
Most common base used for rectal suppository
Cocoa butter
Made from triglycerides from palm, palm kernel, and coconut oils with self-emulsifying glyceryl monostearate and polyoxyl stearate.
Fattibase
From triglycerides derived from coconut oil
Wecobee
From triglycerides of saturated fatty acid C12-C18
Witepsol
Most frequently used in preparation of vaginal suppository
Glycerinated gelatin
this base does not melt on body temperature but rather dissolve slowly in the body’s fluid.
Polyethyleme glycols
also called macromelting range test
melting range test
measures the liquefaction time of rectal suppositories in an apparatus that IN-VIVO condition
Liquefaction/softening time test
the rate IN-VITRO release of drug substance from suppositories
Dissolution testing
designed as a method for measuring the fragility or brittleness of suppository.
Breaking test
are sterile, small, usually cylindrical-shaped solid objects 3.3mm in diameter and 8mm in length.
Pellets
what is the most used vehicles for sterile product
water
polyethylene glycol, propylene glycol, fixed oil, and benzyl benzoate are examples of…
Sterile: Non-aqueous solution:
what type of glass is preferred for parenterals
Type I: Highly resistant borosilicate glass
what type of glass is preferred for buffered aqueous solution and for dry powders and oleaginous solution
Type II: Treated soda lime glass
what type of glass is preferred for dry powders and oleaginous solutions.
Type III: Soda lime glass
what type of glass is preferred for tablets, oral solutions, suspensions, ointments, and extractives.
Type NF: General purpose soda lime glass
