SAS 6 Flashcards
What are the uses of Semi-solids?
- Vehicle for topically applied drugs
- Emollient
- Protective of occlusive dressing on the skin
this is widely used substance in semisolids besides water
Petrolatum and mineral oil
is a complex mixture of semisolids containing hydrocarbon aliphatic, cycle, saturated, unsaturated branch, and unbranched substances in varying proportions
Hydrocarbons
is obtained from petroleum acid and is preferred for those that have lower viscosity.
Mineral oil
is employed to increase the viscosity of mineral oil to prevent separation from an ointment
Hydrocarbon wax
are used in water removable creams as an emulsifier to develop a certain consistency in the cream
Stearic acid
are used in creams as AUXILLIARY emulsifiers and emollients.
Stearyl alcohol and cetyl alcohol
is the most commonly used in ointment vehicles
Petrolatum
What are the recognized vehicles for semisolids?
Absorption bases
hydrocarbon bases
water-soluble bases
water-removable bases
An oil in water emulsion and that upon application and rubbing in the skin, it vanishes.
Water-removable bases
are hydrophilic mixtures formed by the addition of substance miscible with hydrocarbons and possessing polar groups such as SO4, sulfonate, carboxyl hydroxyl, or an ether linage
Absorption base
These are prepared from mixtures of high and low molecular weights of polyethylene glycol
Water-soluble base
Water soluble base with low molecular weight are _______, with moderately higher molecules are unctuous, and with high molecular weights are _______.
Water soluble base with low molecular weight are LIQUID , with moderately higher molecules are unctuous, and with high molecular weights are SOLID.
Water soluble bases are also known as
greaseless ointment bases
Anhydrous ointments are manufactured by the _______ _______.
fusion method
what are the three ways of mixing phases in emulsion?
Simultaneous blending of the phases
external
dispersed phases
This type of mixing phases is good for large batch operation
Simultaneous blending of the phases
This type of mixing phases is useful for emulsion system with a low dispersed phase
external
This type of mixing phase is useful for many emulsion system
dispersed phase
_________ may be used in ophthalmic preparation against bacterial or fungal contamination.
Boric acid
Provide 2 shapes in rectal suppository
Torpedo
bullet
Provide 3 shapes in vaginal suppository
Ovoid
Cone
Globular
Provide 1 shape in urethal
Pencil-like
synonym of vaginal suppositories
pessaries
synonym of urethral suppositories
bougies
SUPPOSITORY: relieves nausea and vomiting and as tranquilizer
Chlorpromazine and Prochlorperazine
SUPPOSITORY: opioid analgesia
Morphine and Oxymorphone
SUPPOSITORY: relieves migraine
Ergotamine tartrate
SUPPOSITORY: NSAID and antipyretic
Indomethacin
SUPPOSITORY: relieves nausea and vomiting
Ondansetron
Most frequently employed as suppository base
Fatty bases
Most common base for rectal suppository
Cocoa butter
SUPPOSITORY FATTY BASE: Made from triglycerides from palm, palm kernel, and coconut oils.
Fattibase
SUPPOSITORY FATTY BASE: From Triglycerides from COCONUT OIL
Wecobee
SUPPOSITORY FATTY BASE: From SATURATED FATTY ACIDS
Witepsol
Most frequently use suppository base for vaginal insertion
Glycerinated gelatin
The simples and oldest method of preparing suppository
Hand molding
a preparation of suppository that results in a more elegant appearance than hand molding
Compression molding
The most commonly used method in producing suppositories both in small and large scale.
Pour molding
An automated method for molding suppositories that is directly to their wrapping material
In-package molding
SUPPOSITORY TEST: Measures liquefaction time of rectal suppositories in apparatus that stimulates in vivo condition.
Liquefaction
SUPPOSITORY TEST: Designed as a method for measuring the fragility or brittleness of suppositories
Breaking test
SUPPOSITORY TEST: Testing the rate of in vitro release of drug substances from suppository
Dissolution test
are fever producing organic substances arising from microbial contamination
pyrogens
Injection for asthma
Aminophylline
Injection for stimulant in treating emergency cardiac and respiratory failure
Caffeine and Sodium benzoate
Injection as local anesthetic
Procaine hydrochloride
Injection for diabetes
Insulin
What is type 1 glass container for parenterals
High resistant borosilicate glass
what is type 2 glass container for parenterals
Treated soda lime glass
what is type NP glass for parenterals
General purpose soda lime glass
A type of parenteral glass preferred for parentals
Type 1: Highly resistant borosilicate glass
A type of parenteral glass that is for buffered aqueous solution and for dry powders and oleaginous solution
TYPE 2: Treated soda lime glass
A type of parenteral glass that is for dry powders and oleaginous solution
TYPE 3: Soda lime glass
A type of parenteral glass that is for tablets,suspension, ointments,nd extractives
TYPE NF: General purpose soda lime glass
These are used to seal opening of cartidges, vials and bottles providing a material soft and elastic enough to permit entry and withdrawal of hypodermic needle.
Rubber closures
Provide 3 filter type for parenterals
Asbestos pad
Cellulose ester membrane
Sintered glass candles
what is the principal material of asbestos pad
Asbestos fiber and wood cellulose
what is the principal material of cellulose ester membrane
Cellulose nitrate, Cellulose acetate
what is the principal material of diatomaceous earth
Diatoms(80%), Silicon dioxide, Iron (III) oxide, and other
what is the principal material of sintered glass candles
Borosilicate glass
what is type 3 glass for parenterals
Soda lime glass
what is the principal material of glazed porcelain candles
Clay, silicon dioxide
