SAS 6 Flashcards
what are the 3 polyenes antibiotic?
Amphotericin B, Natamycin, Nystatin
extracted from streptomyces noursei
Nystatin
extracted from streptomyces natalensis
Natamycin
extracted from streptomyces nodosus
Amphotericin B
what is the active constituent of flucytosine?
5-fluorouracil
what is fluorouracil can act on?
RNA AND DNA
this is administered with amphotericin B to prevent resistance?
Flucytosine
what are the 3 phenols under antifungal?
Ciclopirox Olamine - CLPO
Clioquinol - Clioqui
Haloprogin
PHENOL: agent of choice in the treatment of cutaneous candidiasis, tinea corporis….
Ciclopirox olamine
PHENOL: the second line of choice for the treatment of onychomycosis
Ciclopirox olamine
other words of clioquinol?
Vioform
Vioform is best for?
Jock itch and athlete’s foot
cure rates is high but expensive
Haloprogin
From caprylic acid
Sodium caprylate
this requires the use keratolytic agent
Benzoic acid
what is the old but famous formulation of benzoic acid?
Whitfield’s ointment
6% benzoic acid
6% salicylic acid
is one of the better fatty acids for use as a fungicide although low cure rates
Undecylenic acid
is used as a fungicide particularly on adhesive tape
Zinc propionate
a mitotic spindle poison
Griseofulvin
INHIBITS SQUALENE EPOXIDASE that is for ergosterol synthesis
Allylamines
ALLYLAMINES: 1% conc. of cream and gel for topical-related fungal infections
Naftifine
ALLYLAMINES: has not been approved in the US for oral administration
Terbinafine
ALLYLAMINES: 1% in creams, powders, aerosols, gels, and solutions for topical-related fungal infection.
Tolnaftate
inhibits Ianosterol 14-demethylase
Azole antifungals agent
More effective against Torulopsis glabrata than other azoles
Tioconazole
has an adverse effects of hepatoxicity and problems with sex hormones
Ketoconazole
an important substitution of ketoconazole
Itraconazole
why itraconazole is better substituent than the ketoconazole?
more effective and none ketoconazole’s adverse effects
contains two triazole moieties and has an exception of being soluble in water
Fluconazole
Approved for the treatment of invasive aspergillosis and refractory infections Scedosporium apiospermum and Fusarium spp
Fluconazole
a class of antifungal that targets fungal cell wall
Echinocandins
an antifungal agent that is non-toxic and non-irritant
Propionic acid
prepared from caprylic acid
Sodium caprylate
adhesive type antifungal agent
Zinc propionate
obtained from distillation of castor oil
10-undenoic acid
its efficacy is from the release of acetic acid
Triacetin
poor antifungal agent
keratolytics
beside athletes foot and jock’s itch what does clioquinol can treat?
Trichomonas vaginalis vaginitis
what is the drug in flucytosine in RNA?
Fluororibonucleotide triphosphate
what is the drug in flucytosine in DNA?
5-Fluorodeoxyuridine monophosphate
a 26 membered ring in polyenes
Natamycin (streptomyces natalensis)
what does inhibition of squalene oxidase does to do a fungi cell?
interruption in the biosynthesis of ergosterol
what are the imidazoles
BECTOMKS
Butoconazole
Econazole
Clotrimazole
TIOCONAZOLE
Oxiconazole
Miconazole
Ketoconazole
Sulconazole
what are the triazoles
VFPIT
Voriconazole
Fluconazole
Posaconazole
Itraconazole
TERCONAZOLE
for patients 13 years and above
Posaconazole
treatment of burns
Nitrofurazone
treatment of UTI caused by susceptible strains of E. coli
Nitrofurantoin
inhibits squalene epoxidase
Allylamines (naftifine, tolnaftate, terbinafine)
