LAS 4 - ANTIEPILECTICS Flashcards

1
Q

WHAT ARE THE 3 HYDANTOINS?

A

PHENYTOIN, MEPHENYTOIN, ETHOTOIN

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2
Q

CONSIDER AS IMIDAZOLINE-2,4-DIONE HETEROCYCLIC SYSTEM

A

HYDANTOINS

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3
Q

WHAT IS THE IMPACT OF PHENYL SUBSTITUENT IN P5 IN HYDANTOINS?

A

ANTI-EPILEPTIC ACTIVITY

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4
Q

WHAT IS THE IMPACT OF ALKYL SUBSTITUENT IN P5 IN HYDANTOINS?

A

SEDATION ACTIVITY

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5
Q

WHAT IS THE MOA OF PHENYTOIN?

A

BLOCKAGE OF CA+ AND NA+( NON-SELECTIVE)

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6
Q

HAS THE AE OF HIRUSTISM, GUM HYPERTROPHY…

A

PHENYTOIN (HYDANTOINS)

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7
Q

-DIONE
TRIMETHADIONE, PARAMETHADIONE ARE…

A

OXAZOLISINEDIONES

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8
Q

-IMIDE
PHENSUMIDE, METHSUXMIDE, AND ETHOSUXIMIDE ARE…

A

SUCCINIMIDES

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9
Q

FIRST-LINE-DRUG FOR GENERALIZED ABSENCE SEIZURE

A

ETHOXSUXIMIDE

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10
Q

FIRST-LINE-DRUG FOR STATUS EPILEPTICUS

A

DIAZEPAM

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11
Q

KNOWN FOR ITS BROAD SPECTRUM ACTIVITY

A

VALPROIC ACID

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12
Q

TRIMETHADIONE IS?

A

PROTOTYPE OF OXAZOLIDINEDIONES

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13
Q

IS A BRANCHED-CHAIN (SATURATED) FATTY ACID THAT COMPRISES A PROPYL SUBSTUTUENT ON A PENTANOIC ACID STEM

A

VALPROIC ACID

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14
Q

WHAT SEIZURES DOES VALPROIC ACID ARE EFFECTIVE?

A

ABSENCE
MYOCLONIC PARTIAL
TONIC-CLONIC SEIZURES

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15
Q

LAMOTRIGINE, GABAPENTIN, VIGABATRIN, AND FUNCTIONALIZED AMINO ACID ARE…

A

NOVEL ANTIEPILEPTICS

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