LAS 4 - ANTIEPILECTICS Flashcards
WHAT ARE THE 3 HYDANTOINS?
PHENYTOIN, MEPHENYTOIN, ETHOTOIN
CONSIDER AS IMIDAZOLINE-2,4-DIONE HETEROCYCLIC SYSTEM
HYDANTOINS
WHAT IS THE IMPACT OF PHENYL SUBSTITUENT IN P5 IN HYDANTOINS?
ANTI-EPILEPTIC ACTIVITY
WHAT IS THE IMPACT OF ALKYL SUBSTITUENT IN P5 IN HYDANTOINS?
SEDATION ACTIVITY
WHAT IS THE MOA OF PHENYTOIN?
BLOCKAGE OF CA+ AND NA+( NON-SELECTIVE)
HAS THE AE OF HIRUSTISM, GUM HYPERTROPHY…
PHENYTOIN (HYDANTOINS)
-DIONE
TRIMETHADIONE, PARAMETHADIONE ARE…
OXAZOLISINEDIONES
-IMIDE
PHENSUMIDE, METHSUXMIDE, AND ETHOSUXIMIDE ARE…
SUCCINIMIDES
FIRST-LINE-DRUG FOR GENERALIZED ABSENCE SEIZURE
ETHOXSUXIMIDE
FIRST-LINE-DRUG FOR STATUS EPILEPTICUS
DIAZEPAM
KNOWN FOR ITS BROAD SPECTRUM ACTIVITY
VALPROIC ACID
TRIMETHADIONE IS?
PROTOTYPE OF OXAZOLIDINEDIONES
IS A BRANCHED-CHAIN (SATURATED) FATTY ACID THAT COMPRISES A PROPYL SUBSTUTUENT ON A PENTANOIC ACID STEM
VALPROIC ACID
WHAT SEIZURES DOES VALPROIC ACID ARE EFFECTIVE?
ABSENCE
MYOCLONIC PARTIAL
TONIC-CLONIC SEIZURES
LAMOTRIGINE, GABAPENTIN, VIGABATRIN, AND FUNCTIONALIZED AMINO ACID ARE…
NOVEL ANTIEPILEPTICS