SAS 2 - PHYSICOCHEMICAL PROPERTIES OF ORGANIC MEDICINAL AGENTS Flashcards
What is physicochemical
is the influence of the physical and chemical attributes of a compound or the active drug on its effect
Give 5 properties that influence the physicochemical?
solubility
dissociation constant
molar refractivity
ionization
drug shape
complexation
bioisosterism
what are the 3 expressions/ units in solubility?
mass of solute per volume of solvent
mass of solute per mass of solvent
moles of solute per volume
give some methods that can modify drug structure in drug design?
Use of co-solvents
addition of polar groups (carboxylic acid, ketone, amines)
complexation
surfactants
reduce intrarmolecular forces
provide examples of co-solvents?
polyethylene glycol
propylene glycol
ethanol
sorbitol
what is the another word of complexation?
chelation
how complexation/chelation occur?
though proton donor-accepting process
what is it formally called the proton/acceptor of proton in complexation/chelation?
Lewis acid-base reaction
Define intermolecular forces
the area between two or more molecules of the same compounds
Define intramolecular forces
the area between two atoms of the same compound
Why do intermolecular increases boiling point?
due to polymeric aggregate
why do intramolecular decreases boiling point?
due to chelation which prevents the formation of intermolecular forces
what increases solubility?
increased in hydrogen bonding
complete the sentence: if the anion of acid was stabilized by _________ _______ ___ _______________ ______ it would increase the strength of acid.
hydrogen bonding of intramolecular forces
In Spectroscopic properties…hydrogen bonding shifts the position of bands in _________ and _____ spectra of organic compounds
infrared and NMR spectra of organic compounds