REVIEWER Flashcards

1
Q

Which of the ff. is used topically in the treatment of burns?

Nitrofurazone
Furazolidone
Nitrofurantoin
Nifurtimox

A

Nitrofurantoin

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2
Q

Imidazole antifungal

Voriconazole
Posaconazole
Fluconazole
Miconazole

A

Miconazole

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3
Q

Agent of choice for the treatment of bacterial gastroenteritis caused by gram- negative bacilli.

Ciprofloxacin
Nalidixic acid
Sparfloxacin
Ofloxacin

A

Ciprofloxacin

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4
Q

Act as noncompetitive inhibitors of (1,3)-β-d-glucan synthase, enzyme complex that forms stabilizing glucan polymers in fungal cell wall

Natamycin
Griseofulvin
Micafungin
Naftifine

A

Micafungin

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5
Q

Acts as a tight-binding noncompetitive inhibitor of enzyme inositol phosphorylceramide synthase which is an enzyme essential for fungal sphingolipid biosynthesis

Anidulafungin
Flucytosine
Aureobasidin A
Ciclopirox olamine

A

Aureobasidin A

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6
Q

Which of the ff. Is an inhibitor of squalene epoxidase?

Terbinafine
Naftifine
Tolnaftate
All of the above

A
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7
Q

Which of the ff. concentrates at keratin precursor cells found in nails, skin & hair w/c are gradually exfoliated & replaced by new tissues?

Ketoconazole
Amphotericin B
Flucytosine
Griseofulvin

A

Griseofulvin

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8
Q

Which of the ff. causes leakage of both potassium ion & cell lysis at same concentration?

Amphotericin B
Nystatin
Natamycin
None of the above

A

Natamycin

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9
Q

Which of the ff. provides the best distribution of the currently marketed quinolones?

Enoxacin
Ciprofloxacin
Lomefloxacin
Levofloxacin

A

Ciprofloxacin

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10
Q

7: Potent taeniacide that causes rapid disintegration of worm segments & the scolex

Niclosamide
Bithionol
Oxamniquine
Ivermectin

A

Niclosamide

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11
Q

7: Which of the ff. blocks interneuron-motor neuron transmission in nematodes by stimulating release of the inhibitory neurotransmitter GABA?

Niclosamide
Bithionol
Oxamniquine
Ivermectin

A

Ivermectin

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12
Q

7: Which of the ff. irreversibly blocks glucose uptake in susceptible helminths, thereby depleting glycogen stored in the parasite?

Mebendazole
Thiabendazole
Pyrantel pamoate
Piperazine

A

Mebendazole

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13
Q

7: Which of the ff. blocks response of ascaris muscle to acetylcholine causing flaccid paralysis in the worm w/c is dislodged from intestinal wall & expelled in feces?

Mebendazole
Thiabendazole
Pyrantel pamoate
Piperazine

A

Piperazine

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14
Q

7: Which of the ff. is effective topically & systematically as antidote for poisoning caused by arsenic, antimony, mercury, gold & lead?

Suramin sodium
Dimercaprol
Sodium stibogluconate
Melarsoprol

A

Dimercaprol

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15
Q

7: Which of the ff. Is used in the treatment of West African sleeping sickness?

Nifurtimox
Benznidazole
Eflornithine
Atovaquone

A

Eflornithine

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16
Q

7: Protoplasmic poison that inhibits protein synthesis in protozoal & mammalian cells by preventing protein elongation

Iodoquinol
Emetine
Metronidazole
Diloxanide furoate

A

Emetine

17
Q

7: Which of the ff. Is used to treat skin lesions caused by Mycobacterium ulcerans?

Clofazimine
Cyloserine
Capreomycin
Dapsone

A

Clofazimine

18
Q

7: Used as a pediculicide for the treatment of head lice.

Benzyl benzoate
Lindane
Crotamiton
Permethrin

A

Permethrin

19
Q

7: Which of the ff. Is an inhibitor of the bacterial dihydrofolate reductase?

Sulfamethoxazole
Trimethoprim
Pyrazinamide
Dapsone

A

Trimethoprim

20
Q

8: This quinine derivative appears to disrupt mitochondrial electron transport in protozoa

Halofantrine
Lumefantrine
Atovaquone
Artemisinin
Quinine

A

Atovaquone

21
Q

8: Used in fixed combination with artemether for uncomplicated falciparum malaria in many countries.

Halofantrine
Lumefantrine
Atovaquone
Artemisinin
Quinine

A

Lumefantrine

22
Q

8: Which is not used for chemoprophylaxis because of its potential for quinidine-like cardiotoxicity (QT prolongation) and embryotoxicity

Halofantrine
Lumefantrine
Atovaquone
Artemisinin
Quinine

A

Halofantrine

23
Q

8: Which of the ff. is metabolized in the food vacuole of the parasite forming toxic free radicals and is the standard of care for all chloroquine-resistant malaria?

Halofantrine
Lumefantrine
Atovaquone
Artemisinin
Quinine

A

Artemisinin

24
Q

8: Which of the ff. may cause cinchonism?

Halofantrine
Lumefantrine
Atovaquone
Artemisinin
Quinine

A

Quinine

25
Q

8: Which of the ff. Is a blood schizonticide?

Chloroquine
Pyrimethamine
Sulfadoxine
Primaquine
Proguanil

A

Chloroquine

26
Q

8: Which of the ff. may cause folic acid deficiency when used in high doses?

Chloroquine
Pyrimethamine
Sulfadoxine
Primaquine
Proguanil

A

Pyrimethamine

27
Q

8: Which of the ff. is bioactivated to cycloguanil?

Chloroquine
Pyrimethamine
Sulfadoxine
Primaquine
Proguanil

A

Proguanil

28
Q

8: Which of the ff. forms quinoline-quinone metabolites, which are electron-transferring redox compounds that act as cellular oxidants?

Chloroquine
Pyrimethamine
Sulfadoxine
Primaquine
Proguanil

A

Primaquine

29
Q

8: Which of the ff. may cause GI distress, rash, headache; auditory dysfunction and retinal dysfunction at high doses?

Chloroquine
Pyrimethamine
Sulfadoxine
Primaquine
Proguanil

A

Chloroquine

30
Q

9: Cephalosporin of choice for Community acquired pneumonia

A

CEFUROXIME AXETIL
CEFTRIAXONE
CEFUROXIME

31
Q

9: Anti- staph Penicillin that causes interstitial nephritis

A

METHICILLIN

32
Q

9: Is a drug with a monocyclic B- lactam ring with a spectrum of activity limited to aerobic gram negative rods

A

AZTREONAM

33
Q

9: isolated from Streptomyces cattleya

A

THIENAMYCIN

34
Q

10: Classified as a ketolide, differs from macrolide by the lack of α-L-clabinose at 3- position of the erythronolide A ring, resulting in a 3-keto function

A

TELITHROMYCIN

35
Q

10: Obtained from Pseudomonas fluorescens and used for topical treatment of impetigo, eczema, & folliculitis secondarily infected by susceptible bacteria (staphylococci, beta-hemolytic streptococci)

A

MUPIROCIN