SARS-CoV19 facts

Question 1

what Baltimore class

Answer 1

4

Question 2

how large is the genome

Answer 2

30 KB

Question 3

what is the R0

Answer 3

3

Question 4

what is the latency period

Answer 4

5.6 days average

Question 5

is it enveloped or capsulated

Answer 5

lipid envelope

& Nucleocapsid

Question 6

what is a nucleocapsid

Answer 6

layer surrounding the genetic material - including nucleic acids and proteins

Question 7

what surface proteins does it have

Answer 7

spike glycoprotein
protein E
protein M

Question 8

what is the function of protein E

Answer 8

interferes with epithelial cell-cell junctions

Question 9

what is protein M involved in

Answer 9

virus assembly

Question 10

what does the receptors bind to

Answer 10

ACE2 on pneumocytes

Question 11

what is the symptoms

Answer 11

fever, cough, running nose, diarrhoea

Question 12

how can we diagnose

Answer 12

PCR
lateral flow testing
neutralisation assays
ELISA

Question 13

describe the genome

Answer 13

30Kb
no polyprotein
each protein is transcribed separately
NO SEGMENTED GENOME

Question 14

why is evolution slow

Answer 14

no segmented genome - reassortment cannot occur

Question 15

what does R0 mean

Answer 15

the number of secondary infections in a totally susceptible population

Question 16

treatment for SARS-CoV2

Answer 16

rest & rehydration
antiviral therapy
vaccine programme
respirators in severe cases

Question 17

name a antiviral used to treat covid (as well as HIV)

Answer 17

ritonavir

Question 18

what is the mode of action of ritonavir

Answer 18

a protease inhibitor
- may inhibit enzymes involved in processing viral RNA

approved for use in UK
no strong evidence for efficacy