Influenza Flashcards
what is the R0 of influenza
2-4
describe the envelope structures
round lipid envelope
no capsid
what two proteins are embedded in the lipid envelope
neuraminidase
haemagglutinin
what is the genome enclosed in
nucleocapsid
what type of genome is it
segmented genome
what does a segmented genome mean
instead of existing as a single molecule, it exists as several pieces - each encoding a separate protein
what do spike proteins bind to
silica acid on glycoproteins
is evolution frequent
yes - assortment occurs frequently - producing new viruses
how does transmission occur
inhaling airborne droplets from an infected individual
what does influenza do
destroys respiratory epithelial cells - leaving host vulnerable to secondary infections (staph. aureus)
wha Baltimore class
5 (-ssRNA)
which viral surface proteins is involved in cell entry
haemagglutinin
which viral surface protein is involved in viral exit
neuraminidase
which two proteins commonly undergo antigenic shift
H and N
what is the subtype of Spanish flu and 2009 swine flu
H1N1
