Sarcomere Structure Flashcards
Describe the T tubules
- Walls are continuous with the sarcolemma
* Fluid within is continuous with the external environment
Describe how the T tubules and the sarcoplasmic reticulum are connected
With junctions: involve 2 integral membrane proteins, one in the T tubule membrane and the other in the membrane of the sarcoplasmic reticulum
What is the Sarcolemma?
True cell membrane and encloses the muscle fibre
What is the role of Titin?
• To provide elasticity and stablilize the myosin
What is the Myofibril?
Predominately composed of actin and myosin filaments
Describe the ultrastructural basis of the I band
• Actin filaments bisected by the Z line
Where is the Endomysium?
Separates the muscle fibres
Describe the ultrastructural basis of the H zone
Region of A band which contains only myosin filaments
Define a sarcomere
The portion of a myofibril that lies beween 2 successive z disks
Describe Tropomyosin
- Regulatory protein
* Overlaps the binding sites of actin for myosin and inhibits interaction when in the relaxed state
Describe Troponin
- Regulatory, calcium binding protein
- Forms a complex with the other proteins of the thin filament (actin and tropomyosin)
- Binds to Ca2+ reversibly and once bound, changes conformation to pull the tropomyosin away from the myosin interaction sites
- Ca2+ binding to troponin regulates skeletal muscle contraction because it moves the tropomyosin away and allows myosin to interact with the actin
Describe the T tubule protein
- Modified voltage-sensitive Ca2+ channel
* Dihydropyridine receptor
What are muscle fibres arranged in?
Bundles of fasiculi
What are the contractile proteins of the sarcomere?
- Actin
- Myosin
- Tropomyosin
- Troponin complex
Describe the protein found in the SR membrane
- Ryanodine receptor
* Forms a Ca2+ channel