Sarcoidosis - Slocum Flashcards
1
Q
Symptoms
A
- fever
- malaise
- cough
- weight loss
- dyspnea
- arthritis in ankle and legs
- 50% of cases are incidentally on CXR
2
Q
Physical findings
A
Can be GRUELING:
- Granulomas
- Rheumatoid arthritis
- Uveitis
- Erythema nodosum
- Lymphadenopathy
- Interstitial fibrosis
- Negative TB
- Gammaglobulinemia
3
Q
CXR findigns
A
- Stage 1: bilateral hilar lyphadenopathy
Stage II: hilar adenopathy and pulm infiltrates - Stage III: isolated pulm infiltrates
4
Q
Lab findings
A
- Serum ACE elevated
- hypercalcemia, hypercalciuria
- increased alk phos
- lymphopenia
- may show leukopenia
- Elevated ESR
- Skin test anergy
- serum protein electrophoresis will show polyclonal gammopathy
5
Q
PFT findings
A
- Restrictive pattern
- FEV/FVC increases to 100%
- Decreased TLC
- decreased diffusion capacity
6
Q
Bronchoalveolar lavage findings
A
increased lymphocytes and high CD4/CD8 ratio
7
Q
Treatment
A
Systemic corticosteroids
good prognosis.
