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[Ther 201] E2 > Samplex 2015 Set C > Flashcards

Samplex 2015 Set C Flashcards

1
Q

Mechanism of action of direct adrenergic agonists

A. Increases synthesis of NE
B. Binds and activates adrenergic receptors
C. Inhibition of MAO
D. Inhibits reuptake from synaptic cleft

A

B

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2
Q

Adrenergic receptor on JG Cells

A. Alpha 1
B. Alpha 2
C. Beta 1
D. Beta 2

A

C

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3
Q

this drug with can improve contractility but can also cause vasodilatation should not be taken as a sole adrenergic drug in patients with heart failure and hypotension

A. Dobutamine
B. Dopamine
C. Norepinephrine
D. Phenylephrine

A

B

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4
Q

Selective beta-2 adrenergic agonists are useful in which of the following conditions

A. Hypertension
B. Heart failure
C. Preterm labor
D. Arrythmia

A

C

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5
Q

Sympathomimetic effects in the CNS include the following EXCEPT:

A. Excessive urge to sleep in inappropriate situations
B. Elevation of mood
C. Euphoria
D. Psychosis

A

A

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6
Q

A beta-1 selective blocker with partial activity which will minimize, if not prevent precipitation of asthma and bradycardia.

A. Acetabulol
B. Timolol
C. Propanolol
D. Esmolol

A

A

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7
Q

Incorrect association between histamine and its distribution in organs.

a. H1 – extravascular smooth muscle
b. H2 – gastric parietal cells
c. H3 – CNS
d. H4 - myocardial cells

A

D

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8
Q

not H1 antagonist

a. cimetidine
b. chlorophenydramine
c. diphenhydramine
d. loratidine

A

A

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9
Q

Incorrect about Kallikrein-kininogen-kinin/KKK system:

a. Bradykinin causes vasodilation and cough
b. High molecular weight kinninogen is important in activation of intrinsic clotting pathway
c. Aprotinin which inhibits kallikrein à reverse bleeding due to heparin
d. Tissue damage cannot activate KKK

A

D

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10
Q

Not a function of 5ht

a. Regulation of GI motility and peristalsis
b. Bronchodilation
c. Central chemical transmitter for tryptaminergic neurons of the brain
d. Precursor of melatonin

A

B

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11
Q

Incorrect match between the 5HT receptor antagonist / agonist drugs with their clinical use

a. 5HT3 Antagonist / ondansetron – nausea, vomiting
b. 5HT4 agonist / Cisapride – anxiety/depression
c. 5HT 1D agonist / Sumatripan – migraine
d. 5HT2A Antagonist / Ketaneserin – hypertension

A

B

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12
Q

Example of non-selective 5HT receptor antagonist:

a. Buspirone
b. Trazodone
c. Ergotamin
d. Ketanserin

A

C

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13
Q

The gastrointestinal bleeding from aspirin is considered:

a. side effect
b. extension effect
c. drug toxicity
d. medication error

A

A

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14
Q
  1. Autacoids involved in inflammatory reaction, EXCEPT

a. Histamine
b. Bradykinin
c. Serotonin
d. Prostanoids
e. Angiotensin II

A

E

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15
Q

The following physiologic effects are mediated by histamine EXCEPT

a. Vasodilatation
b. Increased vascular permeability
c. Relaxation of intestinal smooth muscles
d. Stimulation of sensory nerve endings

A

C

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16
Q

H1 blockers (traditional / older antihistamines) have the following effects:

a. Promote sedation
b. Relieve allergic manifestations on the skin and mucous membrane
c. Emesis
d. All of the above
e. A and B only

A

D

17
Q

Which of the following is least sedating

a. Loratadine
b. Chlorpenamine
c. Diphenhydramine
d. Clemastine

A

A

18
Q

What are the therapeutic uses of the H1 blockers? ALL EXCEPT

a. As a sleeping aid
b. For countering motion sickness
c. To moisten the mouth and throat
d. To relieve itching and rashes in allergic disease

A

C

19
Q

Body functions where 5-HT in involved

a. Fertility
b. Feeding
c. Sleeping
d. Mentation
e. All of the above

A

E

20
Q

The enzyme responsible for converting tryptophan to serotonin belongs to what class

a. Lipoxygenase
b. Hydroxylase
c. Peroxidase
d. Transferase

A

B

21
Q

Prostanoids have the following actions/clinical significance

a. Platelet function
b. Inflammatory reaction
c. Reproduction
d. A and B only
e. All of the above

A

E

22
Q

Which of the following anti-inflammatory agents is unique that it binds to its receptor irreversibly?

a. Ibuprofen
b. Mefenamic acid
c. Acetaminophen
d. Aspirin

A

D

23
Q

An example of lipoxygenase inhibitor is:

a. Celecoxib
b. Zileuton
c. Montelukast
d. Misoprostol

A

B

24
Q

Histamine

a. has powerful effects on smooth and cardiac muscles
b. endothelial cells and nerves
c. more effect on guinea pigs than humans
d. gastric acid secretion
e. AOTA

A

E

25
Q

Traditional antihistamines with sedative effect include

a. Diphenhydramine
b. Loratadine
c. Cetirizine
d. AOTA
e. A&C only

A

A

26
Q

Actions mediated by H1 blocker but not through H1 receptor

a. Bronchia; and GI smooth muscle relaxation
b. Endothelial constriction resulting in increased muscular permeability
c. Dilation of vascular smooth muscle from NO from EDRF
d. sedative, antinausea effect
e. AOTA

A

D

27
Q

Serotonin is found in:

a. Enterochromaffin cells, 90% of the body
b. Platelets which are able to concentrate the amine by means of active SERT
c. Nerve endings, particularly brain serotonergic neurons as transmitter.
d. AOTA
e. B&C only

A

D

28
Q

5HT in brain serotonergic neurons are involved in

a. mood, depression, anxiety
b. sleep, apetite and vomiting
c. pain, temperature regulation, migraine
d. AOTA
e. A and C only

A

D

29
Q

Selective serotonin include:

a. Sumatriptan, 5HT1A/1D antagonist, for migraines and cluster headaches
b. buspirone, 5HT1 agonist used as a widely accepted anxiolitic
c. Ondesterone, 5HT3 for chemotherapy antiemesis
d. AOTA
e. B&C only

A

B

30
Q

Angiotensin II and III effects are reversed by

a. renin inhibitors of synthesis or release
b. angiotensin converting enzyme inhibitors
c. kininase II inhibitors
d. angiotensin receptor antagonist
e. AOTA

A

E

31
Q

The potency of ACE inhibitors like captopril can be explained by a dual action:

a. inhibition of synthesis of a powerful vasoconstrictor
b. inhibition of destruction of a powerful vasodilator
c. stimulation of synthesis of a powerful vasodilator
d. AOTA
e. A and B only

A

E

32
Q

Prostaglandin sunthesis is blocked through several pathways

a. lipoxygenase pathway, site of action of leukotriene inhibitors
b. cyclooxygenase pathway, site of action of aspirin and NSAIDS
c. Phospholipase enzyme, site of direct action of corticosteroids
d. AOTA
e. B&C only

A

B

[Ther 201] E2 (8 decks)

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