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[Ther 201] E2 > Samplex 2015 Set B > Flashcards

Samplex 2015 Set B Flashcards

1
Q

sympathetic activation will lead to the following action:

A. Pupil dilation
B. Bronchoconstriction
C. Bradycardia

A

A

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2
Q

Possible mechanisms of action of indirect adrenergic agonists

a. binds to adrenergic receptors
b. blocks MAO
c. enhances reuptake of NE from the synaptic cleft
d. enhances activity of COMT

A

B

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3
Q

Adrenergic Receptor predominantly found in the heart.

A. Alpha 1
B. Alpha 2
C. Beta 1
D. Beta 3

A

C

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4
Q

Adrenoreceptor coupled to Gq protein and especially found in smooth muscles.

A. Alpha 1
B. Alpha 2
C. Beta 1
D. Beta 2

A

A

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5
Q

True of the structure-activity relationship

A. Increase in alkyl substitution in the amino group, increase in Beta receptor activity
B. Decrease the substitution in the benzene ring, decrease in potency
C. substitution in the alpha-carbon prolongs drug activity
D. AOTA

A

D

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6
Q

Beta 2 adrenergic agonists are most useful with the condition:

A. Hypertension
B. Asthma
C. Heart Failure
D. Arrhythmia

A

B

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7
Q

Beta 1 receptor activation effects include

A. stimulation of renin release
B. skin vasodilation
C. insulin release
D. skeletal muscle tremor

A

A

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8
Q

Postsynaptic activation of Alpha 1 receptor will lead to:

A. Cutaneous vasodilation
B. Lipolysis
C. Nasal Decongestion
D. Uterine relaxation

A

C

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9
Q

Patient with septic shock was started on low dose of dopamine, what is an expected effect?

A. Vasoconstrict
B. Decrease cardiac output
C. Bradycardia
D. Increase renal blood flow

A

D

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10
Q

Alpha 2 agonist activation will most likely lead to:

A. vasoconstriction
B. bronchodilation
C. decrease in insulin and rennin release
D. AOTA

A

D

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11
Q

An adolescent brought to the ER presenting with aggressive behaviour, tremor, anxiety, paranoid state, hypertension, and tachycardia was diagnosed to have metamphetamine abuse. Which of the ff. is the action of amphetamine?

A. It binds directly to Alpha 1 and Beta 1 receptors
B. It displaces NE from vesicles
C. It enhances MAO activity
D. It promotes exocytotic release of NE

A

B

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12
Q

Alpha-1 blockers are beneficial in:

A. hypotension
B. asthma
C. urinary retention
D. nasal decongestion

A

C

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13
Q

Adverse effects of adrenoceptor blocker

A. bronchoconstriction – alpha blockade
B. increase intraocular pressure – beta blockade
C. hypertension
D. severe bradycardia

A

D

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14
Q

Reserpine action

A. direct agonist
B. inhibits VMAT
C. inhibits MAO
D. AOTA

A

B

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15
Q

The additional effect of some B-blockers like labetalol and pirdolol which can prevent untoward effects like asthma and bradycardia is due to:

A. partial agonist effect
B. potassium blockade
C. local anesthetic effect
D. AOTA

A

A

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16
Q

α1 = α2; β1&raquo_space; β2

A. Dobutamine
B. Epinephrine
C. Norepinephrine
D. Phenylephrine
E. Terbutalin
A

C

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17
Q

α1 = α2; β1 = β2

A. Dobutamine
B. Epinephrine
C. Norepinephrine
D. Phenylephrine
E. Terbutalin
A

B

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18
Q

β1 > β2&raquo_space;» α

A. Dobutamine
B. Epinephrine
C. Norepinephrine
D. Phenylephrine
E. Terbutalin
A

E

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19
Q

β2&raquo_space; β1&raquo_space;>α

A. Dobutamine
B. Epinephrine
C. Norepinephrine
D. Phenylephrine
E. Terbutalin
A

A

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20
Q

Diarrhea in diabetics with autonomic neuropathy

A. Clonidine
B. Dobutamine
C. Epinephrine
D. Terbutalin

A

A

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21
Q

Preterm labor

A. Clonidine
B. Dobutamine
C. Epinephrine
D. Terbutalin

A

D

22
Q

Anaphylactic shock

A. Clonidine
B. Dobutamine
C. Epinephrine
D. Terbutalin

A

C

23
Q

A selective α1 antagonist

A. Atenolol
B. Esmolol
C. Phenoxybenzamine
D. Prazosin
E. Propranolol
A

D

24
Q

Long-acting selective β-blocker

A. Atenolol
B. Esmolol
C. Phenoxybenzamine
D. Prazosin
E. Propranolol
A

A

25
Q

Non-selective β-blocker

A. Atenolol
B. Esmolol
C. Phenoxybenzamine
D. Prazosin
E. Propranolol
A

E

26
Q

An α-receptor irreversible antagonist

A. Atenolol
B. Esmolol
C. Phenoxybenzamine
D. Prazosin
E. Propranolol
A

C

27
Q

β-blocker with the shortest half-life

A. Atenolol
B. Esmolol
C. Phenoxybenzamine
D. Prazosin
E. Propranolol
A

B

28
Q

Sympathetic activation will lead to which of the following physiologic function/s

           	A. Pupillary constriction
           	B. Bronchodilation
           	C. Gluconeogenesis
           	D. Micturition
           	E. Lipogenesis
A

B

29
Q

Activation of which of the following adrenoreceptors inhibits adenyl cyclase causing a decrease in cAMP

           	A. Alpha-1
           	B. Alpha-2
           	C. Beta-1
           	D. Beta-3
           	E. D-1
A

B

30
Q

Which of the following is TRUE about structure-activity relationship of direct adrenergic agonists?

a. increasing the size of alkyl substituents on the amino group tends to increase alpha-receptor activity
b. decreased substitution in the benzene ring reduces bioavailability
c. decreased substitution in the benzene increases potency
d. substitution in the alpha-carbon prolongs drug action
e. all of the above

A

D

31
Q

Postsynaptic action of alpha-1 receptors will lead to the following effect

a. nasal decongestion
b. decreased peripheral vascular resistance
c. lipolysis
d. decreased insulin and rennin secretion
e. uterine relaxation

A

A

32
Q

A patient with septic shock was started on a sympathomimetic expected to increase both cardiac contracitility and heart rate. This drug is MOST LIKELY.

a. low dose dopamine
b. dobutamine
c. high dose epinephrine
d. terbutaline
e. norepinephrine

A

B

33
Q

A patient rushed to the emergency room for anaphylactic shock was given intramuscular epinephrine. Resulting vasoconstriction is mediated by which adrenergic receptor:

a. alpha-1
b. alpha-2
c. beta-1
d. beta-2
e. beta-3

A

A

34
Q

In an experiment by Arinze and Kawai in 1983, glycogenolysis in hepatocytes isolated from fed guinea pigs was stimulated by catecholamines with the following order of potency: Isoproterenol> epinephrine&raquo_space; norepinephrine. This order of potency is characteristic of which adrenoreceptor:

a. alpha-1,
b. alpha-2
c. beta-1
d. beta-2
e. beta-3

A

C

35
Q

An adolescent brought to the emergency room presenting with aggressive behaviour, tremor, anxiety, paranoid state, hypertension, and tachycardia was diagnosed to have metamphetamine abuse. Which of the following is TRUE about the action of Amphetamine?

a. It inhibits vesicular monoamine transporter
b. It inhibits norepinephrine transporter
c. It prevents vesicular uptake of norepinephrine
d. It promotes nonexocytotic release of norepinephrine
e. All of the above

A

D

36
Q

Endocrine effects of beta-blockers include which of the following:

a. inhibition of beta-1 receptor mediated glycogenolysis and glucose release
b. lipolysis
c. decreased VLDL and HDL
d. Peripheral conversion of thyroxine in triiodothyronine
e. inhibition of beta-1 receptor mediated renin release

A

E

37
Q

A 63 year old male patient presenting with both hypertension and urinary obstruction secondary to benign prostatic hypertrophy will benefit most from which of the following drugs:

a. metropolol
b. clonidine
c. prazosin
d. ephedrine
e. reserpine

A

C

38
Q

A patient diagnosed to have pheochromocytoma, a tumor of the adrenal medulla causing excessive release of epinephrine and norepinephrine, was started on a non-selective alpha-antagonist, an example of which is

a. terazosin
b. yohimbine
c. methyldopa
d. clonidine
e. phentolamine

A

E

39
Q

Which additional effect of some beta-blockers like Labetalol and Pindolol can prevent untoward effects like precipitation of asthma and excessive bradycardia

a. partial agonist effect
b. potassium blockade
c. local anesthetic action
d. Na channel blockade
e. all of the above

A

E

40
Q

Postynaptic activation of Alpha- 1 receptors will lead to the following cellular effects

a) . Decreased intracellular calcium
b) . Increased Camp
c) . Increased IP3 and DAG
d) . Inhibition of phospholipase activity

A

C

41
Q

a patient with “warn” septic shock present with hypotension and generalized vasodilation high dose dopamine intravenous infusion was started. Which adrenoceptor does dopamine act to constrict the vessels?

a) . Beta-1
b) . Alpa-1
c) .Alpha-2
d) .d1

A

B

42
Q

A patients rushed to the emergency room for anaphylactic shock was given intramuscular epinephrine.which of the following are expected effects of the drug.

a) .Bronchodilation
b) .vasodilation
c) .decreased cardiac contractility
d) .Pupillary constriction

A

A

43
Q

In an experiment by Arinze and kawai in 1983, glycogenolysis in hepatocytes isolated fromfed guinea pigs was stimulated by catecholamines with the following order of potency: Isoproterenol> Epinephrine»Norepinephrine. This order of potency is characteristic of which adrenoceptor:

a) . Alpha-1
b) .Alpha-2
c) . Beta-1
d) . Beta-2

A

D

44
Q

Which of the following depends on normal stores of catecholamines for its sympathomimetic action.

a) . Phenylephrine
b) . clonidine
c) . Amphetamine
d) . Terbutaline

A

C

45
Q

Which of the following is TRUE regarding substitutions on this compound.

a) . Decreased substitution on the benzene ring increases potency of sympathomimetic
b) . Increasing the size of alkyl substituents on the amino group tend to increase beta-receptor activity
c) . Substitution on the beta carbon blocks oxidation by MAO
d) . Decreased subsititution on the benzene ring leads decreased distribution of the molecule to the central nervous system

A

B

46
Q

Which of the following drug will decrease heart rate in a normal heart but has little or no effect in a denervated heart

a) .Isoproterenol
b) .Dobutamine
c) . Prazosin
d) .Phenylephrine

A

D

47
Q

Metabolic effects of Beta- blockade include which of the following :

a) .Complete inhibition of lipolysis
b) .Increased VLDL and decreased HLD with chronic use
c) .Increased peripheral conversion of thyroxine to triiodothyronine
d) . Increased rennin secretion

A

B

48
Q

Which of the following is the drug of choice for a hypertensive patient with benign protastic hypertrophy and urinary obstruction:

a) . Metoprolol
b) .Clonidine
c) .Prazosin
d) . Ephedrine

A

C

49
Q

A patient diagnosed to have pheochromocytoma, a tumor of the adrenal medulla causing excessive release of epinephrine and norepinephrine, was started on a non- selective alpha-anatagonits, an example of which is

a) . Yohimbine
b) . Methyldopa
c) . Terazosin
d) .Phenoxybenzamine

A

D

50
Q

The following is NOT a clinical use of beta-adrenoceptor antagonist:

a) . Portal hypertension
b) . Glaucoma
c) . Hypothyroidism
d) . Chronic heart failure

A

C

[Ther 201] E2 (8 decks)

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