Samplex 2015 Set A Flashcards
Which of the following is predominantly sympathetic?
A. heart
B. arterioles
C. Urinary bladder
D. Ciliary muscle
B
Which of the following is ligand-gated?
A. 5-HT1
B. 5-HT2a
C. 5-HT3
D.5-HT4
C
Which of the following is the BBB less impermeable?
a. cerebral ischemia
b. premature infants
c. area postrema
d. median eminence
e. aota
E
Which of the following are characteristics of voltage gated sodium channels?
a. found on the initial segment of dendrites
b. modulate rate of neural discharge
c. mediates signal from the cell body to the nerve terminal
d. action is of a slower time scale
C
true of membrane delimited metabotropic receptors
a. g protein directly activates ion channel
b. activation of presynatic calcium channels
c. inhibition of postsynaptic potassium channel
d. aota
A
which of the following glutamate channel is partly controlled by ligand gated channels.
a. KA
b. AMPA
c. NMDA
d. all of the above
C
NE enhances excitatory inputs by which of the following mechanisms:
a. hyperpolarize neurons by increase k+ conductance
b. disinhibition of inhibitory local units
c. blocking of potassium conductance
d. b and
D
Which of the following is selective for GABAb receptors?
A. Diazepam
B. Baclofen
C. Phenobarbital
D. Muscraribic adrenergic and blocker
B
Which of the following agents acting on the autonomic ganglia is used clinically to treat hypertension?
A. Trimetaphan
B. Hexamethonium
C. Epibatidine
D. Lobeline
A
Which drug is responsible for blocking the transport of Ach and forms false neurotransmitter?
A. Vesamicol
B. Triethylcholine
C. Botulinum toxin
D. Hexamithonium
B
Atropine may cause all of the following except:
A. Cycloplegia
B. Dry mouth
C. Hypotension
D. Mydriasis
C
A patient is rushed to the emergency room after ingesting an unknown substance. On examination, the patient was restless, had miotic pupils, excessive salivation and lacrimation and wheezes were noted on auscultation of the lungs. Given the ff drugs, which of the ff would most likely be the drug ingested?
A.Tyramine
B. Vesamicol
C. Scopolamine
D. Parathion
D
A patient who has renal insufficiency is to undergo surgery for removal of a renal cyst. If use of a neurotransmitter blocker is warranted, which of the following would probably be the safest to use?
A. Tubocurarine
B. Atracurium
C. Pancuronium
D. Doxacurium
B
Pralidoxime splits the phosphorylated convalent bonds if given early in organophosphate poisoning.
A. True
B. False
A
Large doses of cholinesterase inhibitors have no effect on autonomous innervation.
A. True
B. False
B
Depolarizing and nondepolarizing neuromuscular blockers bear structural resemblance to acetylcholine.
A. True
B. False
A
Non-depolarizing blocking drugs do not produce significant autonomic effects.
A. True
B. False
B
Tetanic stimulation removes blockade in depolarizing phase 1.
A. True
B. False
B
Which of the following is the rate limiting step in the synthesis of acetylcholine?
A. Active transport of choline into cell
B. Entry of neurotransmitter into vesicle
C. Acetylation of choline to acetyl-CoA
D. Hydrolysis of acetylcholine
A
Which of the following is a centrally acting cholinesterase inhibitor used in the treatment of Alzheimer’s type of dementia?
A. Pyridostigmine
B. Rivastigmine
C. Edrophonium
D. Pilocarpine
B
A patient is rushed to the emergency room after ingesting an unknown substance. On examination, the patient was restless, had miotic pupils, excessive salivation and lacrimation and wheezes were noted on auscultation of the lungs. Given the following drugs, which of the following would most likely be the drug ingested?
A. Neuromuscular blockers
B. Botulinum toxin
C. Organophosphates
D. Datura stramonium
C
A patient is rushed to the emergency room after ingesting an unknown substance. On examination, the patient was restless, had mitotic pupils, excessive salivation, and lacrimation and wheezes were noted upon auscultation. Given the following drugs, which of the following could be the unknown substance?
a. Trimetaphan
b. Vesamicol
c. Scopolamine
d. Parathion
D
[T/F] Pralidoxime splits the phosphorylated covalent bond if given early in the organophosphate poisoning
T
[T/F] Large doses of cholinesterase inhibitors have no effect on the autonomic ganglia
F
[T/F] Depolarizing and non-depolarizing drugs have a structural resemblance to acetylcholine
T
[T/F] Non-depolarizing drugs have no effect on the autonomic ganglia
F
[T/F] Tetanic stimulation relieves neuromuscular blockade in phase 1 depolarizing block
F
