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[HS 202] E2 (Pathology) > Samplex 2014 Set B > Flashcards

Samplex 2014 Set B Flashcards

1
Q

Caseating material in granulomas are mostly derived from:

a. neutrophil
b. macrophage
c. lymphocyte
d. bacilli

A

B

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2
Q

What is a characteristic tuberculoid leprosy has:

a. Adequate T-cell mediated immunity
b. Adequate B-cell mediated immunity

A

A

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3
Q

The pseudomembrane of bacillary dysentery is derived from:

a. necrosis of epithelial cell
b. granulomatous reaction
c. exudative material
d. cytoproliferative reaction

A

C

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4
Q

The enterotoxin that is responsible for illness in cholera is an:

a. endotoxin
b. exotoxin
c. neurotoxin
d. integral part of the cell wall

A

B

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5
Q

Adult cases of gonorrheal conjunctivitis is transmitted by:

a. sexual intercourse
b. reactivation
c. auto-inoculation
d. mosquitoes

A

C

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6
Q

Long-term complications of gonococcal salpingitis include:

a. ectopic pregnancy
b. ovarian fibrosis
c. abortion
d. bacteremia

A

A

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7
Q

Most feared complication of Dengue in the defervescence state.

a. Thrombocytosis
b. Thrombocytopenia
c. Endotoxic Shock
d. Renal Failure

A

B

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8
Q

Major cause of the common cold:

a. Respiratory Syncitial Virus
b. Coxsackie Virus
c. Rhinovirus
d. Herpes Simplex Virus

A

C

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9
Q

Salk polio vaccine is composed of

a. formaldehyde inactivated virus
b. attenuated trivalent viral culture
c. combined inactivated and attenuated virus
d. monovalent attenuated virus

A

A

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10
Q

Associated with squamous cell carcinoma of cervix

a. HPV type 16
b. HPV type 1
c. HSV type 1
d. HSV type 2

A

A

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11
Q

A classmate in med school developed flu like illness a few days after the start of the sem. A cbcb showed wbc count of 15,000 cells per ml, 55% of which are lymphocytes. A peripheral blood smear has a no. Of atypical forms. IgM antibodies to a certain virus were positive.

Which is the possible causative agent?

a. HSV
b. EBV
c. Dengue
d. HPV2

A

B

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12
Q

A classmate in med school developed flu like illness a few days after the start of the sem. A cbcb showed wbc count of 15,000 cells per ml, 55% of which are lymphocytes. A peripheral blood smear has a no. Of atypical forms. IgM antibodies to a certain virus were positive.

Of the antibody above, the ff is likely :

a. responsible for clearing the virus from the human body
b. protective to the patient against future infection by the same virus
c. will decrease in titer in a few weeks
d. persist for life

A

D

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13
Q

Vibrio cholerae adherence and toxin genes are produced by:

A. Plasmids
B. Glycoproteins
C. Salt Concentration
D. Iron Deprivation

A

D

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14
Q

A 5 y.o. female presents with conjunctivitis, high grade fever, and rinorrhea. Pedia suspects causative agent is a single stranded enveloped RNA of the Paramyxoviridae family.

Transmission of disease is caused by

a. mosquito bite
b. autoinnoculation
c. respiratory droplets
d. intimate contact with case

A

C

Disease is likely measles

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15
Q

A 5 y.o. female presents with conjunctivitis, high grade fever, and rinorrhea. Pedia suspects causative agent is a single stranded enveloped RNA of the Paramyxoviridae family.

Viremia in this case is

a. persistent
b. transient
c. recurring
d, absent

A

B

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16
Q

A 5 y.o. female presents with conjunctivitis, high grade fever, and rinorrhea. Pedia suspects causative agent is a single stranded enveloped RNA of the Paramyxoviridae family.

A defective form of the virus

a. nasopharyngeal carcinoma
b. brain tumor
c. subsclerosal panenchepalitis
d. burkitt lymphoma

A

C

Subacute sclerosing panencephalitis (SSPE) is a progressive neurological disorder of children and young adults that affects the central nervous system (CNS). It is a slow, but persistent, viral infection caused by defective measles virus-cannot form its envelope.

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17
Q

The single most common abnormality of the dominant oncogenes involves a point mutation of:

a. RAS
b. cFMS
c. cyclin D1
d. RET

A

A

18
Q

The most common abnormality in dominant genes in human tumors?

a. RAS
b. cFMS
c. cyclin D1
d. RET

A

A

19
Q

Dysregulation of MYC expression resulting from translocation of the MYC gene occurs in:

a) Chronic myelogenous leukemia
b) Neuroblastoma
c) Small cell lung carcinoma
d) Burkitt lymphoma

A

B

20
Q

Reduplication of DNA segments producing several copies of proto-oncogenes is exemplified by:

a. C-erb-B2 in breast cancer
b. Bcr-Abl in chronic myelogenous leukemia
c. Rb gene in retinoblastoma
d. Bcl-2 gene in follicular lymphoma

A

A

21
Q

An example of an apoptosis gene:

a. RAS
b. n-MYC
c. RB
d. bcl-2

A

D

22
Q

Example of a hybrid chromosome:

a. t(8,14)
b. t(14,18)
c. t(9,22)
d. trisomy 21

A

C

23
Q

The activation of APC is an example of:

a. signal transduction
b. transcription regulation
c. DNA repair
d. gene amplification

A

A

24
Q

Knudson’s hypothesis is associated with:

a. ataxia-telangiectasia
b. Fanconi anemia
c. retinoblastoma
d. Bloom syndrome

A

C

25
Q

“molecular policeman”

a. Rb
b. p53
c. RAS
d. n-MYC

A

B

26
Q

The protein product of NF-1 is involved in:

a. nuclear transcription
b. signal transduction
c. RNA repair
d. cell cycle disruption

A

B

27
Q

The β-catenin way is regulated by the protein product of ___________

A. APC gene
B. Rb gene
C. Bcr-abl gene
D. K-ras gene

A

A

28
Q

Reduced cell death is associated with:

a. xenoderma pigmentosum
b. adenomatous polyposis coli
c. retinoblastoma
d. follicular lymphoma

A

D

29
Q

Aflatoxin is strongly associated with the development of ______.

A. nasopharyngeal carcinoma
B. hepatic cell carcinoma
C. Burkitt’s lymphoma
D. glandular lymphoma

A

B

30
Q

Exposure to vinyl chloride is associated with the development of ______.

A. liver hemangiosarcoma
B. lung carcinoma
C. melanoma
D. gastric carcinoma

A

A

31
Q

An example of an oncogenic RNA virus is:

A. HTLV-1
B. HBV
C. EBV
D. HPV

A

A

32
Q

Cervical carcinoma is strongly related to infection by

A. HPV 1
B. HPV 4
C. HPV 7
D. HPV 16

A

D

33
Q

Epstein Barr Virus (EBV) preferentially infects and immortalizes:

a. Tonsillar epithelium
b. Tonsillar stroma
c. B cell
d. T cell

A

C

34
Q

What characteristic of neoplasm is the hallmark of malignancy?

a. anaplasia
b. invasion
c. metastasis
d. high mitotic count

A

C

35
Q

Which of the following is a malignancy?

a. choristoma
b. lipoma
c. lymphoma
d. hemangiosarcoma

A

C

36
Q

True of anaplasia:

a. refers to the similarity to normal comparison
b. refers to histopathologic changes only
c. exemplified by the loss of normal polarity
d. exemplified by nuclear pyknosis

A

C

37
Q

A mass of normal cells found in an ectopic location is known as:

A. hemartoma
B. neoplasia
C. teratoma
D. choristoma

A

D

38
Q

Immunohistochemistry is beneficial in:

a. Detection of metastasis
b. Immunophenotyping of leukemia
c. Determination of malignancy
d. Categorization of unclassified tumor

A

D

39
Q

Image guide aspiration biopsy is best used in:

a. parotid gland tumor
b. lung tumor
c. cervical tumor
d. lymphadenopathy

A

B

40
Q

alpha-fetoprotein is used as a tumor marker for patients undergoing therapy for this type of neoplasm.

a. testicular germ cell tumor
b. cervical cancer
c. breast cancer
d. paraneoplastic syndrome

A

A

[HS 202] E2 (Pathology) (5 decks)

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