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Oral Bio II > Salivary Glands/Secretion > Flashcards

Salivary Glands/Secretion Flashcards

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Biology 101 flashcards
1
Q

What protein will cause the lack of salivary glands to develop as well as limbs or hair follicles?

A

p63

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2
Q

What is p63?

A

A transcription factor that transcribes mRNA for certain genes

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3
Q

What are the five general stages of salivary gland development?

A

Prebud, Initial bud, Pseudoglandular, Canalicular, and Terminal bud

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4
Q

During what stage will a salivary gland form duct lumen?

A

The canalicular stage

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5
Q

During the pseudoglandular stage what is proliferating more, mesenchyme or epithelium?

A

Epithelium is proliferating at a high rate

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6
Q

The probed stage begins with what?

A

Thickening of the probud stage?

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7
Q

At what stage does the beginning of a duct form?

A

Initial bud stage (appears as a dimple in the oral cavity)

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8
Q

What drives the formation of a salivary gland?

A

Mesenchyme

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9
Q

Does the mesenchyme determine the secretions of a gland?

A

No that is up to the epithelium

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10
Q

What two genes are important in salivary gland development?

A

Fgf2b and Fgf10

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11
Q

What happens if the EDAR gene is blocked?

A

Branching of the gland won’t occur

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12
Q

What happens to cells that occupy the future lumen in the salivary gland?

A

They undergo apoptosis to form the lumen

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13
Q

What is expressed in cells that will form the lumen in the canalicular?

A

Caspase-3 protein (*triggers/induces apoptosis)

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14
Q

Which transcription factors define the cells in the salivary buds during the terminal bud stage?

A

Mucin transcriptase E14, and Mucin E17

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15
Q

What specific attachment proteins are seen in the salivary ducts?

A

tight junctions and desmosomes

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16
Q

What initiates the thickening of epithelium to form a salivary gland?

A

Mesenchyme

17
Q

Does parasympathetic or sympathetic innervations of salivary glands develop first?

A

Parasympathetic develops with gland (*sympathetic doesn’t develop until after birth)

18
Q

What parasympathetic neurotransmitter stimulates the submandibular gland?

A

Acetylcholine (otic nerve for parotid; submandibular for SMG and SLG)

19
Q

What sympathetic neurotransmitter stimulates the salivary gland?

A

Norepinephrine (comes from cervical ganglion)

20
Q

What happens if there’s a mutation or malfunction in Fgf10?

A

aplasia of lacrimal and salivary glands (doesn’t develop)

21
Q

What development stages are affected by mutation of Fgf10?

A

Prebud and Initial bud

22
Q

Mutation of Fgf2 causes what?

A

Lacrimo-auriculo-dento-digital Syndrome (eyes, ears, mouth, and hands)

23
Q

Mutation of Fgf2, 3 and 10 effect which stages of salivary gland development?

A

Initial bud and Psuedoglandular

24
Q

Mutations in what genes can cause Hypohidrotic Ectodermal Dysplasia?

A

EDAR, EDA, and EDARADD

25
Q

Mutation in EDAR effects what to form?

A

Salivary Ducts

26
Q

Major salivary glands produce ___% of the saliva each day?

A

90%

27
Q

What are Myoepithelial cells?

A

They’re contracting cells that help push the saliva out of the bud

28
Q

What does the parotid secrete?

A

serous

29
Q

What does the submandibular gland secrete?

A

mostly serous but some mucous

30
Q

What does the sublingual secrete?

A

Most all mucous

31
Q

What do minor salivary glands secrete?

A

Mucous

32
Q

Norepinephrine binds to which receptor?

A

Adrenergic

33
Q

Acetylcholine binds to which receptor?

A

M3R

34
Q

What do secretory cells pump into the lumen to start salivary flow?

A

Na, Cl, and then water follows

35
Q

What happens to salivary contents in the duct?

A

Na and Cl are taken out of the saliva, and K and HCO3 are pumped into the saliva

36
Q

Which receptor causes the release of Na and Cl into the salivary lumen?

A

IP3

37
Q

What three things make up saliva?

A

H2O, K+, and HCO3

38
Q

What tonicity is saliva?

A

Hypotonic

39
Q

What are the three ways that proteins are secreted into the saliva?

A

Major regulated, Minor regulated, and Constitutive-like

Oral Bio II (8 decks)

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