Regeneration and Repair Flashcards
What are the four phases of tissue repair?
hemostasis, inflammatory, reparative phase, and wound contraction
What is formed during hemostasis?
A fibrin scaffold
What causes platelet aggregation by interacting with platelet surface proteins?
von Willebrand Factor
How can platelets bind collagen?
direct binding via GPVI (glycoprotein VI) and α2β1 integrin
What initiates primary hemostasis?
Exposure of collagen in subendothelium to von Willebrand Factor
What anchors platelets together in a primary hemostasis?
Fibrinogen
Primary hemostasis is clotting of ________ and secondary hemostasis is clotting of ________.
platelets, blood
What is the extrinsic pathway of secondary hemostasis?
Factor VII (not normally in blood) initiates the cascade to convert prothrombin to thrombin
What does thrombin do?
it converts soluble fibrinogen into insoluble fibrin
What is the intrinsic pathway to secondary hemostasis?
Endothelium is damaged which exposes collagen and uses factors normally found in the blood
What does fibrin do in a clot?
It makes a net that traps blood cells
What is the first inflammatory cell to arrive at a wound? And the second?
Neutrophils, macrophages
When is granulation tissue formed?
During the proliferative phase and is done by migration of epithelial cells
Besides epithelial cells migrating and proliferating to heal a wound, what other cells are proliferating?
Fibroblasts, but more importantly Endothelial cells via TGFβ, VEGF, and Fgf2
What special cells draw wound edges together?
Myofibroblasts, and they use actin/myosin to attach to CT
