Bone Flashcards
Bone is what percentage inorganic and organic?
67% inorganic, 33% organic (28% collagen, 5% noncollagen proteins)
Parathyroid hormone does what to bone?
Stimulates osteoclasts to break down the bone
The inner and outer layers of the periosteum are made of what?
Outer = fibrous Inner = cellular and vascularized
What composes compact bone?
osteons, interstitial lamellae, and circumferential lamellae
What connects haversian canals?
Volkmann Canals
What is endosteum?
Loose connective tissue covering the inner surface of cancellous and compact bone
osteoclasts are activated in inflammation by what signal factors?
IL-1B, and TNF-a
What is the zone between the howship’s lacunae and intact bone?
Lamina limitans
What can trigger bone cell recruitment?
tissue damage, inflammation, or repair signals
What do osteoblasts use to activate osteoclasts?
RANKL (on osteoblast) binds to RANK (on osteoclast)
What is produced by osteoblasts and binds to RANKL to prevent osteoclast activation?
OPG (osteoprotegerin)
Long bones typically form by what method of development?
endochondral bone formation
The mandible is formed through what method of bone formation?
Intramembranous ossification
What makes up primary spongiosa in endochondral ossification?
Mixed spicules
What kind of bone is formed first in intramembranous formation?
Woven bone
