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Oral Path 2, Exam 2 > Salivary Gland Neoplasms > Flashcards

Salivary Gland Neoplasms Flashcards

1
Q

3 benign salivary neoplasms

A
  1. Pleomorphic adenoma
  2. Papillary cystadenoma lymphomatosum (Warthin tumor)
  3. Canalicular adenoma
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2
Q

5 malignant salivary neoplasms

A
  1. Mucoepidermoid carcinoma
  2. Polymorphous adenocarcinoma
  3. Adenoid cystic carcinoma
  4. Acinic cell carcinoma
  5. Carcinoma ex-pleomorphic adenoma
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3
Q

Salivary gland neoplasms have a slight ___ predilection

A

Female

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4
Q

Most common site for salivary gland neoplasms

A

Parotid gland

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5
Q

Most common minor gland for salivary gland neoplasms

A

Palate

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6
Q

Most common site for malignancy in major glands

A

Sublingual gland

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7
Q

Most common site for malignancy in minor glands

A

Retromolar region and tongue

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8
Q

“Benign mixed tumor”

A

Pleomorphic adenoma

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9
Q

Most common salivary gland neoplasm

A

Pleomorphic adenoma

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10
Q

___% of Pleomorphic adenomas are in the ___ gland

A

80%, Parotid

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11
Q

Pleomorphic adenomas are ___ unless they’re in the palate

A

Moveable

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12
Q

Palatal Pleomorphic adenomas are usually located:

A

Lateral to the midline

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13
Q

Treatment for Pleomorphic adenoma in the parotid gland

A

Remove lesion with the involved LOBE

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14
Q

Treatment for Pleomorphic adenoma in the submandibular gland

A

Remove lesion and the involved GLAND

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15
Q

Treatment for Pleomorphic adenoma in the hard palate

A

Remove lesion, including overlying mucosa down to periosteum

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16
Q

Treatment for Pleomorphic ademoma in the soft palate, labial and buccal mucosa

A

Enucleation

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17
Q

___% of Pleomorphic adenomas undergo malignant transformation if not removed

A

5%

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18
Q

Which location has more Pleomorphic adenoma recurrences: Parotid or Minor glands?

A

Parotid

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19
Q

“Warthin Tumor”

A

Papillary cystadenoma lymphomatosum

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20
Q

Myoepithelial cells in Pleomorphic adenoma may appear plasmacytoid or spindled and can produce:

A

Myxoid stroma, hyaline material, cartilaginous material, or even osteoid

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21
Q

What does Papillary cystadenoma lymphomatosum probably arise from?

A

Salivary duct epithelium entrapped in parotid lymph nodes during development

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22
Q

Papillary cystadenoma lymphomatosum is almost exclusively in the ___ gland (esp. the ___)

A

Parotid, tail

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23
Q

Papillary cystadenoma lymphomatosum has a strong association with _____

A

Smoking

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24
Q

Papillary cystadenoma lymphomatosum shows cystic spaces containing ____ ___

A

Serous fluid

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25
Q

Treatment for Papillary cystadenoma lymphomatosum

A

Surgical excision

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26
Q

Prognosis for Papillary cystadenoma lymphomatosum

A

Good, low recurrence

27
Q

Proliferation of one cell type

A

Monomorphic adenoma

28
Q

The term “monomorphic adenoma” was replaced by ___ ___

A

Canalicular adenoma

29
Q

Canalicular adenoma is more common in ____ glands, especially ____ ___ ___

A

Minor, upper labial mucosa

30
Q

What do central mucoepidermoid carcinomas likely arise from?

A

Odontogenic epithelium containing mucous cells (found in odontogenic cyst lining)

31
Q

Treatment for Canalicular adenoma

A

Enucleation

32
Q

Prognosis for Canalicular adenoma

A

Excellent

33
Q

Most common salivary gland malignancy

A

Mucoepidermoid carcinoma

34
Q

Most common salivary gland malignancy in children

A

Mucoepidermoid carcinoma

35
Q

Minor gland usually involved in Mucoepidermoid carcinoma

A

Palate and Retromolar area

36
Q

Most common salivary gland malignancy in the lips, FOM, tongue

A

Mucoepidermoid carcinoma

37
Q

What should be considered a Mucoepidermoid carcinoma until proven otherwise?

A

Mucocele-appearing lesion in the retromolar area

38
Q

What must Mucoepidermoid carcinoma show in the histology?

A

Intracellular mucin

39
Q

True/False: PAC can have a variety of growth patterns

A

True

40
Q

What stains for intracellular mucin?

A

Mucicarmine

41
Q

Treatment for low-grade Mucoepidermoid carcinoma

A

Wide surgical excision

42
Q

Treatment for high-grade Mucoepidermoid carcinoma

A

Wide surgical excision plus radiation

43
Q

< ____ cm Mucoepidermoid carcinomas have an excellent prognosis

A

2.5

44
Q

2nd most common minor salivary gland malignancy

A

Polymorphous Adenocarcinoma (PAC)

45
Q

PAC is well-demarcated initially, and then becomes ___

A

Infiltrative

46
Q

PAC is almost exclusively in ___ glands

A

Minor

47
Q

True/False: PAC can have a variety of growth patterns

A

True

48
Q

The lesional cells of PAC are usually ____

A

Bland

49
Q

PAC can be confused with ____ ____ carcinoma or ____ ____ ____ adenoma

A

Adenoid cystic carcinoma or carcinoma ex-pleomorphic adenoma

50
Q

Treatment for PAC

A

Wide surgical excision

51
Q

50% of all minor salivary gland ___ ___ ____ are in the palate

A

Adenoid cystic carcinomas

52
Q

In Adenoid Cystic Carcinoma, the ___ and ___ gland are equally effected

A

Parotid and Submandibular

53
Q

Most common malignancy in the submandibular gland

A

Adenoid Cystic Carcinoma

54
Q

Pain is associated with this carcinoma and NSAIDs are unhelpful

A

Adenoid Cystic Carcinoma

55
Q

3 growth patterns of Adenoid Cystic Carcinoma

A
  1. Tubular (well-differentiated)
  2. Cribriform (classic “Swiss cheese” - intermediate)
  3. Solid (poorly-differentiated)
56
Q

Histology of Adenoid Cystic Carcinoma

A
  1. Hyperchromatic basaloid cells
  2. Minimal cytoplasm
  3. Little pleomorphism
  4. Little mitotic activity
57
Q

Treatment for Adenoid Cystic Carcinoma

A

Wide surgical excision and radiation

58
Q

Prognosis for Adenoid Cystic Carcinoma

A

Generally poor

59
Q

What route do most Adenoid Cystic Carcinomas metastasize by?

A

Blood

60
Q

Most acinic cell carcinomas are in the ____ gland

A

Parotid

61
Q

Acinic cell carcinomas often appear _____ (histology)

A

Psuedoencapsulated

62
Q

Malignancy: patient is usually aware of a long-standing, asymptomatic mass that suddenly becomes tender

A

Carcinoma ex-pleomorphic adenoma

63
Q

What do you see in the histology of carcinoma ex-pleomorphic adenoma?

A

Carcinomatous elements that arise in areas of benign pleomorphic adenoma

64
Q

Prognosis for carcinoma ex-pleomorphic adenoma

A

Guarded

Oral Path 2, Exam 2 (6 decks)

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