Saliva Flashcards

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1
Q

Where is the parotid gland located

A

Anterior to the ear, posterior to ramus, inferior to zygomatic arch. Extends from zygomatic arch to angle of mandible

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2
Q

Where is submandibular gland located

A

Inferior and posterior to body of mandible at submandibular fossa. Superficial and deep part wedged by mylohyoid

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3
Q

Where is sublingual gland located

A

Sublingual fossa below mucous membrane next to mandibular canines. Superior to mylohyoid. Anterior to submandibular gland

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4
Q

What is the duct for parotid gland

A

Stenson’s duct. Runs across masseter and pierces buccinator and mucous membrane of cheek to open opposite 2nd molar

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5
Q

What is the duct for submandibular gland

A

Wharton’s. Long tortuous route along floor of mouth then against gravity to open into oral cavity at sublingual papillae

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6
Q

What is the duct for sublingual gland

A

Bartholin’s which opens directly into submandibular duct to drain into sublingual papilla. Ducts of rivinius which are multiple small ducts which open into sublingual fold (extends from sublingual caruncle to posterolateral part of gum

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7
Q

Describe minor salivary glands

A

Located within submucosa with short ducts that open directly onto mucosal surface. Located at oral mucosa except gingiva and anterior palate. Mostly mucous glands, major source of secretory iga. Only von ebners glands located below sulci of circumvallate papillae is serous producing

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8
Q

Describe the saliva produced by the cells that are poorly stained with an empty appearance

A

Mucous acini. Mucin appear unstained. Mucous saliva is carbohydrate rich, viscous, mucin rich, for lubrication to help with swallowing

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9
Q

Describe the saliva from strongly stained cells that are pyramidal in shape with thin basement membrane and narrow apex bordering lumen of acini

A

Serous mucous. Protein rich, rich in amylase, watery secretion to help with digestion

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10
Q

What are the crescent shaped serous cells in mucous acini called

A

Serous semilunes

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11
Q

Who do myoepithelial cells do

A

Contractile cells associated with secretory end pieces and intercalated ducts help to expel saliva from acini into the ducts

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12
Q

What are the 2 stages of saliva production

A

Stage 1: isotonic saliva produced from secretory acini containing water, electrolytes, mucin and proteins

Stage 2: primary saliva passes through duct system, selective reabsorption of Na+ and Cl- and some K+ and HCO3- secreted leading to hypotonic saliva being secreted from excretory duct. Lumen not completely permeable to water

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13
Q

How does smelling food make you salivate

A

Chemo/mechanoreceptors activate parasympathetic receptors, releasing acetylcholine that activates muscarinic receptors. Secretion of watery saliva (rich with digestive enzyme amylase) increases

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14
Q

How does stress give you dry mouth

A

Activate sympathetic neurons, release of norepinephrine, activing b adrenergic receptors resulting in release of small volumes of viscous saliva

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15
Q

Innervation of parotid gland

A

Inferior salivatory nucleus at medulla oblongata, form glossopharyngeal nerve which branches into tympanic branch enter tympanic plexus form lesser petrosal nerve, form otic ganglion, auriculotemporal branch of trigeminal nerve innervates parotid gland

Sympathetic from superior cervical ganglion, fibres travel via external carotid artery

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16
Q

Innervation of submandibular and sublingual glands

A

Superior salivatory nucleus at pons, form facial nerve branches into chorda tympani travels within/hitchhike in lingual nerve, go to submandibular ganglion and innervates glands

Sympathetic from superior cervical ganglion, fibres travel via external carotid artery

17
Q

Innervation of minor palatal salivary glands

A

Superior salivatory nucleus at pons, form facial nerve which branches into greater petrosal nerve, becomes vidian nerve travelling through pterygoid canal, enter pterygopalatine ganglion, maxillary division of trigeminal nerve innervates glands

18
Q

Do cholinergic/muscarinic drugs eg. Pilocarpine increase or decrease salivation

A

Increase

19
Q

What is the function of mucin in saliva

A

Lubricate as negatively charged mucin can form expanded structure

Hydration as negatively charged mucin can bind water

Pellicle formation as negatively charged mucin can bind hydroxyapatite and ca2+ preventing it from being lost

Remove bacteria because mucin can help with agglutination of bacteria, forming a bolus that can be rinsed out. Also helps to disperse bacterio via glycan specific interactions to suppress biofilm formation

20
Q

Why do babies drool so much

A

Teeth. Underdeveloped/weak perioral muscles for swallowing saliva. Produce excessive amount of saliva for various reasons eg underdeveloped digestive system

21
Q

What do salivary proteins do

A

Help to form the salivary pellicle. Help to module microbial colonisation in oral cavity by interacting with dental and mucosal surfaces

22
Q

Function of slatherins and proline rich proteins

A

Prevent precipitation of super saturated calcium phosphate. This is done via binding to hydroxyapatite and calcium, maintaining integrity of the tooth surface

23
Q

How is digestive function of saliva carried out. Use 2 specific enzymes for examples

A

Salivary a amylase which breaks down starch to simpler sugars by cleaving a 1,4 glycosidic bond.

Lingual lipase secreted primarily by von ebner glands which hydrolyse triglycerides into free fatty acids and partial glycerides

24
Q

Why is lingual lipase important in newborn infants

A

Pancreatic lipase need more time to develop

25
Q

What are 5 consequences of hyposalivation

A

Reduced anti microbial factors and reduced remineralisation —> rampant dental caries

Fewer digestive enzymes leading to digestive problems

Reduced acid buffering leading to demineralisation and dental erosion

Reduced anti fungal factors leading to candidal infections

26
Q

What condition may cause unilateral diffuse swelling of salivary gland

A

Sialilothiasis. Calcified mass in salivary duct

27
Q

Give an example of a component of saliva that helps with

  1. Buffer
  2. Demin
  3. Remin
  4. Lubrication
  5. Anti viral
  6. Anti fungal
  7. Anti bacterial
  8. Digestion
  9. Taste
  10. Bolus
A
  1. Hco3-, po43-
  2. Mucin, ca2+
  3. Ca2+, phosphate
  4. Mucin
  5. Mucin, immuniglobulin
  6. Immunoglobulin
  7. Lactoferrin, lysozyme, immunoglobulin
  8. Amylase, lingual lipase
  9. Zinc, water
  10. Mucin, water