SAIDS

Question 1

Hydrocortisone

Answer 1

endogenous glucocorticoid

Equal anti-inflammatory and Na retaining potency

Question 2

prednisolone

Answer 2

synthetic glucocorticoid

Stronger anti-inflammatory potency than Na retaining potency (than other exogenous steroids)

Question 3

Fludrocortisone

Answer 3

synthetic glucocorticoid

Very high Na retaining potency

Used as an aldosterone replacement in Addisons Disease

Question 4

Dexamethasone

Answer 4

synthetic glucocorticoid

No Na retaining potency, only anti-inflammatory potency

Long half life

Question 5

Betamethasone

Answer 5

synthetic glucocorticoid

Question 6

What are the SE of SAIDS

Answer 6

physical and mental dependence
metabolic effects
growth retardation in children (inhibit effects of IGF)
immunosuppression
osteoporosis (increase activity of osteoclasts)
repro effects
MR binding - causing CVS, eye, kidney effects
Cushings syndrome (ACTH independently caused)*
Conn’s syndrome

Question 7

What are the normal effects of steroids

Answer 7

1. Anti-inflammation
   -induce annexin 1 that inhibits PLA2 (so good for treating asthma**)
   -decrease transcription of COX2
   - decrease immune cells and increase anti-inflam mediators IL10
2. Metabolic
   - carbs (anti-insulin, increase gluconeogenesis = hyperglycemia)
   -protein (breakdown)
   -lipids (deposit in face)