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Alyssa Pharmacology > ANS Drugs > Flashcards

ANS Drugs Flashcards

1
Q

NO, 5-HT, ATP, GABA, dopamine, purines, neuropeptides

A

NANC (noradrenergic, noncholinergic)

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2
Q

Neostigmine, Physostigmine

A

Medium acting acetylcholinesterase inhibitors

Notes - carbamyl esters. Physostigmine longer acting than neostigmine. Use to reverse neuromuscular block or myasthenia gravis treatment

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3
Q

Hemicholinium

A

Stops reuptake of choline from synaptic cleft for recycling

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4
Q

Suxamethonium

A

Depolarizing blocking agent (NMJ agonist)

Notes - nicotinic antagonist. binds receptors and stays there blocking further ACh action - used for transient paralysis ex intubation

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5
Q

Tubocurarine

A

Non-depolarizing blocking agent (NMJ antagonist)

Notes - nicotinic antagonist. compeptitive antagonist to ACh

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6
Q

Botulinum

A

Ganglion blocking drug

Notes - nicotinic antagonist. toxin produced by C.diff (toxin BTX-A). local effects causing denervation

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7
Q

Cholinergic receptors

A

Nm - muscle type - neuron to muscle
Nn - nerve type - neuron to neuron
M1 - increase IP3 - excitation - neurons
M2 - decrease cAMP - inhibition - heart
M3 - increase IP3 - excitation - glands, erectile tissue, eye, bronchi

Cholinergic stimulant
- cholinergic toxidrome - DUMBBELSS
- defecation, urination, miosis, bronchospasm, bradycardia, emesis, lacrimation, sweating, salivation

Anticholinergic effects
- opposite of DUMBBELSS
- dry mouth, blurred vision, constipation, glaucoma

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8
Q

Doneprezil, tacrine

A

Acetylcholinesterase inhibitor

Notes - for Alzheimer’s disease

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9
Q

Edrophonium

A

Short acting acetylcholinesterase inhibitor

Notes - Quaternary alcohol. Binds anionic sites only and prevents ACh binding. Used in diagnosis for myasthenia gravis

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10
Q

Echothiopate, Isofluorophate

A

Irreversible acetylcholinesterase inhibitors

Notes - pentavalent phosphorus compounds that phosphorylate ser203 @ active site forming a stable bond. It is reversible within first few hours if pralidoxime or an “oxime” administered

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11
Q

Adrenoceptors

A

A1 - increase IP3 - excitatory - BVs
A2 - decrease cAMP - inhibitory - BVs, pancreatic islets
B1 - increase cAMP - excitatory - kidney, heart
B2 - increase cAMP - excitatory - SMC, ciliary muscle

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12
Q

Propanolol

A

beta adrenoceptor antagonist

Notes - sympatholytic. b1/b2 nonspecific

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13
Q

phentolamine

A

alpha adrenoceptor antagonist

Notes - sympatholytic. a1/a2 nonspecific

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14
Q

ACh, bethanechol

A

Direct-acting muscarinic agonists

Notes - choline esters

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15
Q

Pilocarpine

A

Direct-acting muscarinic agonists

Notes - alkaloid. Used for glaucoma to lower the pressure in the eye

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16
Q

Atropine

A

Muscarinic antagonists

Notes - used for bradycardia associated with MI

17
Q

Hyoscine

A

Muscarinic antagonists

18
Q

Scopalamine

A

Muscarinic antagonists

19
Q

Dicycloverine

A

Muscarinic antagonists

Notes - used for IBS-D

20
Q

Ipratropium

A

Muscarinic antagonists

Notes - used for COPD & asthma

21
Q

Mivacurium, atracurium, vecuronium, pancuronium

A

Non-depolarizing blocking agent (NMJ antagonists)

Notes - nicotinic antagonist.

22
Q

Prazosin

A

alpha adrenoceptor antagonist

Notes - sympatholytic. a1 specific

23
Q

Atenolol

A

beta adrenoceptor antagonist

Notes - sympatholytic. b1 specific

24
Q

Metoprolol

A

beta adrenoceptor antagonist

Notes - sympatholytic. b1 specific

25
Q

Salbutamol

A

beta adrenoceptor agonist

Notes - sympathomimetic. b2 specific

26
Q

Terbutaline

A

beta adrenoceptor agonist

Notes - sympathomimetic. b2 specific

27
Q

Dobutamine

A

beta adrenoceptor agonist

Notes - sympathomimetic. b1 specific

28
Q

Clonidine

A

alpha adrenoceptor agonist

Notes - sympathomimetic. a2 specific

29
Q

Phenylephrine

A

alpha adrenoceptor agonist

Notes - sympathomimetic. a1 specific

30
Q

Nicotine

A

Ganglion stimulating drug

Notes - nicotinic agonist

Alyssa Pharmacology (12 decks)

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