Resp Drugs

Question 1

Terbutaline, Salbutamol

Answer 1

SABA - reliever that bronchodilates & mild inflammatory inhibition

Notes - 1st line drugs. beta2 affinity >b1 affinity. Increases cAMP

Question 2

Formeterol, salmeterol

Answer 2

LABA - reliever that bronchodilates & mild inflammatory inhibition

Notes - 3rd line drugs. SE systemic effects @ high doses (tachy, cardiac dysrhythmia, peripheral vasodilation)

Question 3

Theophylline

Answer 3

methyl xanthine

Notes - blocks PDE. narrow TI, never inhaled. SE >110umol/L nausea, convulsions, arrhythmias & sudden cardiac death if given IV bolus. DDI bc it is CYP metabolized drugs that inhibit CYP & induce CYP. Use - only chronic asthma

Question 4

Aminophylline

Answer 4

Complex of theophylline + ethylenediamine

Notes - more soluble

Question 5

Montelukast, Zafirlukast

Answer 5

Cysteine leukotriene receptor antagonist

Notes - add on to SABA/LABA. inhibits early & late phase response. Use- reduce reactions to aspirin & chronic asthma

Question 6

Ipratropium

Answer 6

SAMA

Notes - anti-cholinergic effects (dry mouth, glaucoma, bladder function)

Question 7

Tiotropium

Answer 7

LAMA

Notes - anti-cholinergic effects (dry mouth, glaucoma, bladder function)

Question 8

Mometasone, beclomethasone, budesonide, fluticasone

Answer 8

IHC for anti-inflammation

Notes - 2nd line drugs (at low dose) that prophylactically inhibit late phase by decreasing cytokine formation in Th2 cells & preventing eosinophil recruitment. SE hoarseness, candidiasis, cough, systemic cushings symptoms @ high doses. Additional controller therapy (at high dose) after LABA

Question 9

Prednisolone

Answer 9

Oral corticosteroid

Question 10

Chromoglycate drugs

Answer 10

mast cell stabilizers that inhibit degranulation