S4.1 Diuretics And Renal Pharmacology

Question 1

Summarise the different types of diuretics found along the nephron

Answer 1

PT: carbonic anhydrase inhibitors and osmotic diuretics (mannitol)
LoH: loop diuretics (furosemide)
DCT: thiazide diuretics (indapamide)
CD: K+ sparing diuretics (amiloride), aldosterone antagonists (spironolactone)

Question 2

What are the ADRs of furosemide?

Answer 2

Ototoxicity, alkalosis

Question 3

What are the ADRs of thiazide diuretics?

Answer 3

Gout, hyperglycaemia

Question 4

What are the ADRs of spironolactone?

Answer 4

Hyperkalaemia, impotence