S11.1 Drugs Effecting Acid Secretion

Question 1

What defensive mechanism does gastric mucosa have from acid and H. Pylori?

Answer 1

Constant cell replication
Mucus membrane barrier
Good vascular supply

Question 2

Describe the features of PPIs

Answer 2

E.g omeprazole, lansoprazole. Oral

Inhibits proton pumps reducing acid secretion

Question 3

Describe the features of H2 receptor antagonists

Answer 3

E.g. ranitidine, Oral

Histamine can’t activate parietal cells to secrete acid. Less effective as only indirectly block proton pumps

Question 4

What is H. Pylori?

Answer 4

Gram negative bacteria found in GI tract, which can cause gastric and duodenal inflammation/ulceration.
Toxic to epithelial cells and degrades mucosal lining

Question 5

How do we diagnose the presence of H. Pylori?

Answer 5

Carbon-13 urea breath test and Stool antigen test.

Question 6

What is the treatment for H. Pylori?

Answer 6

Clarithromcin
Amoxicillin
Lansoprazole (or metronidazole)

Question 7

What is the treatment for GORD?

Answer 7

Lifestyle: weight loss, alcohol reduction.

Then H2RA, then PPI

Question 8

What is the treatment for peptic ulcers?

Answer 8

Give H2RA and PPI for 6 weeks, to eradicate H. Pylori