S3_L4: Drugs for Parkinson's Disease Flashcards
This is a disorder of the extrapyramidal system, presenting with resting tremor, rigidity, postural instability, and bradykinesia
Parkinson’s Disease
TRUE OR FALSE: In PD, there is a reduction in number of cells in substantia nigra. A decrease in DA content is also seen, with too much activity of ACh.
A. Both statements are false
B. Both statements are true
C. Only the 1st statement is true
D. Only the 2nd statement is true
B. Both statements are true
TRUE OR FALSE: L-Dopa acts on the CNS
False
TRUE OR FALSE: In the periphery, Levodopa is converted into dopamine by the peripheral dopa decarboxylase. This protein is also known as aromatic L-amino-acid decarboxylase.
A. Both statements are false
B. Both statements are true
C. Only the 1st statement is true
D. Only the 2nd statement is true
C. Only the 1st statement is true
aromatic L-amino-acid decarboxylase is an enzyme
TRUE OR FALSE: Dopamine itself does not cross the blood-brain barrier and is not effective as a drug.
True
TRUE OR FALSE: PD pts may also present with non-motor s/sx and affect other organs
True
TRUE OR FALSE: Non-motor s/sx includes cognitive impairment, mood disturbances sensory disorders, autonomic dysfunctions, sleep disturbances, and psychotic symptoms
True
The motor sx of PD are attributed to loss of
(1)_____ neurons in the (2)_____
- dopaminergic
- substantia nigra
TRUE OR FALSE: L-Dopa is an immediate precursor of dopamine. It only comes and is administered in 3 forms.
A. Both statements are false
B. Both statements are true
C. Only the 1st statement is true
D. Only the 2nd statement is true
B. Both statements are true
TRUE OR FALSE: Dopamine has effects that are both excitatory and inhibitory.
True
How may dopamine be administered?
Through oral, inhalational, or IV
Abrupt withdrawal of L-Dopa results in what syndrome?
Neuroleptic Malignant Syndrome
TRUE OR FALSE: Neuroleptic Malignant Syndrome present with involuntary movements and muscle rigidity. It may also present with high fever.
A. Both statements are false
B. Both statements are true
C. Only the 1st statement is true
D. Only the 2nd statement is true
B. Both statements are true
TRUE OR FALSE: Levodopa can cross the BBB when given an adjunct medication called carbidopa
True
The following are classic s/sx of PD, EXCEPT:
A. Stooped posture
B. Back rigidity
C. Flexed elbows & wrists
D. Trendelenburg gait
E. None
D. Trendelenburg gait
TRUE OR FALSE: Neurotransmitters may be reuptaken back to the post-synaptic neuron
False, it may go back to the presynaptic neuron
The following are classic s/sx of PD, EXCEPT:
A. Hypomimia
B. Tremors in the head
C. Masked face
D. Forward tilt of trunk
E. Reduced arm swing
B. Tremors in the head
The following are classic s/sx of PD, EXCEPT:
A. Hand tremor
B. Bradykinesia
C. Intention tremor
D. Short stepped gait
E. Shuffling gait
C. Intention tremor
This drug blocks dopamine reuptake in the presynaptic neuron
Amantadine
Enumerate at least 3 pharmacological management used to alleviate PD s/sx.
- Levodopa
- Carbidopa
- Mao-B inhibitors
- COMT inhibitors
- Dopamine agonist
- Amantadine
- Inhibits dopa decarboxylase
- Inhibits the metabolism of dopamine to
3-Methoxytyramine - Inhibits metabolism of dopamine to DOPAC
A. Levodopa
B. Carbidopa
C. Mao-B inhibitors
D. COMT inhibitors
E. Dopamine agonist
F. Amantadine
- B
- D
- C
- Entacapone
- Selegiline
- Bromocriptine
A. Levodopa
B. Carbidopa
C. Mao-B inhibitors
D. COMT inhibitors
E. Dopamine agonist
F. Amantadine
- D
- C
- E
- Pramipexole
- Ropinirole
- Rasagiline
A. Levodopa
B. Carbidopa
C. Mao-B inhibitors
D. COMT inhibitors
E. Dopamine agonist
F. Amantadine
- E
- E
- C
TRUE OR FALSE: Carbidopa acts on the periphery
True