S3 M6 Immunity Flashcards
Tuberculosis
Disease affecting lung parenchyma
associated with poverty
TB spread is
airborne
TB patho
airborne
multiply in alveoli and get transported via blood and lymph
as infected cells die they accumulate in lung causing bronchopneumonia
Can recur
TB infection occurs to weeks after exposure
2 to 10
S/S of EARLY TB
insidious
Low fever
cough
sweats
fatigue
weight loss
As TB progresses S/S includes
Mucopurulent sputum expectorate
Hemoptysis - blood in cough
Elder TB patients have _ pronounced symptoms
Less
If pt presents with positive skin, blood or sputum, for TB
Do history, physical exam, Chest xray, Drug susceptibility testing.
5mm or greater on TB test
Positive
Blood tests for TB
QuantiFERON Gold
T-Spot
rules out Active and Latent infections
Good for BCG vaccinated people
TB meds
Anti-TB agents
INH, Rifampin, Pyrazinamide, Ethambutol
Given for 6 to 12 months
Prolong treatment to ensure eradication
TB drug resistance
Primary - resistance to ONE drug in people who have not had previous treatment
Secondary - resistance to ONE OR MORE in people undergoing therapy
Multi - resistance to TWO agents
TB treatment phases
phase 1: all drugs + Vit B6 for 8 weeks
phase 2: INH and rifampin for 4 to 7 months
Nursing priorities with TB
Airway clearance
Adherence to meds
^ Activity and nutrition
Prevent transmission
Airway clearance with TB interventions
^ fluid intake
Postural drainage
Adherence to meds with TB
Take meds on empty stomach or 1h before meal
Food that messes with TB meds
Tune
Aged cheese
Red wine
Soy sauce
Yeast extract
Rifampin makes what meds less effective
Warfarin
digoxin
corticosteroids
Contact lenses and rifampin
Will be discolored
switch to glasses
Side effects of antiTB meds
Liver/Kidney problems (BUN, creatinine, enzymes)
Hearing loss
Rash
Prevent transmission with TB
Cover mouth
dispose of tissues
Hand hygiene
Do you report TB to the health department
YES
Allergies are related to Ig
IgE
Anaphylaxis
Type I hypersensitivity
Rapid release of IgE
severe life-threatening reaction
Pathophysiology or anaphylaxis
IgE antibodies sense allergen, release histamines, prostaglandins and inflammatory leukotrienes
This results in angioedema, hypotension and bronchoconstriction
Common causes of anaphylaxis
Antibiotics and radiocontrast agents
Penicillin most common culprit
The faster the onset of anaphylaxis
The more severe the reaction
Mild anaphylaxis S/S
tingling and warmth
fullness in mouth and throat
nasal and periorbital swelling
sneezing and tearing of eyes
onset is first 2h of exposure
Moderate anaphylaxis S/S
flushing/warmth/itching
Anxiety
Bronchospasms
edema or airways
cough/wheezing
onset within first 2h
Severe anaphylaxis S/S
Abrupt onset
severe dyspnea
cyanosis
hypotension
V/D
seizures
Treatment for anaphylaxis
Strict avoidance
Epinephrine (EpiPen Auvi-Q)
As nurses we should _ for anaphylaxis
Screen
Venom immunotherapy
Desensitization
Good for those allergic to bees, ants, wasps
Food for those allergic to insulin or penicillin
Med management of anaphylaxis
O2
Epi
Antihistamines
Corticosteroids
IV fluids
After treatment for anaphylaxis watch for rebound reaction which happens…
4 to 8 h after
Nursing management of anaphylaxis
Check airway breathing and vitals
Notify providers
Instructions after recovery, like what to avoid and getting an epipen
Emergency nursing measures for anaphylaxis
Intubating
Admin emergency meds
IV lines + fluids
O2 admin
SLE
Systemic lupus erythematosus
Inflammatory autoimmune disorder
Affects body organs
Lupus
SLE patho
Body recognized one or more components of normal cell nucleus as foreign
Increase in antibodies against those nuclear antigens
Specific increase in B-lymphocyte Stimulator (BLyS)
Factors that contribute to lupus
Genetic
Immunologic
Hormonal
Environmental
SLE manifestations
Fever, malaise, weight loss, anorexia
Most commonly affected system by SLE
Gastrointestinal tract
Liver
Ocular system
Skin manifestations of lupus
Rash on nose bridge and cheeks
With SLE, skin lesions are worsened by
sunlight
ultraviolet light
Earliest symptoms of SLE
Joint problems
Arthralgia
Heart symptoms with SLE
Pericarditis
Hypertension
Dysrhythmias
Valve problems
Kidneys and SLE
Nephritis
Serum creatinine for screening
CNS and SLE
cognitive impairment
seizure
strokes
central and peripheral neuropathy
Diagnosing SLE
History
Physical
Blood tests
Erythematous rash
Erythematous plaque with scale
Sign of lupus
Scalp with SLE
Mouth with SLE
Alopecia
Ulcerations
Lesions of fingertips, elbows, forearms and toes
Vascular lupus
SLE has 11 criteria
if _ are present, lupus is diagnosed
4
Blood work for lupus
Anti-DNA
Anti-ds DNA
Anti-Sm
Mainstay of SLE management
Pain
Immunosuppression
Meds for SLE
Monoclonal antibodies
Corticosteroids
Antimalaria agents
NSAIDS
Immunosuppressive agents
Belimumab
Approved by FDA for SLE
Monoclonal antibody that renders BLyS inactive
Risk factor for corticosteroids and SLE
Osteoporosis
Nursing management focus with SLE
Fatigue
Impaired skin integrity
Body image disturbance
Deficit in knowledge
SLE patients should avoid
SUN
Ultraviolet light
SLE patients need to increase
screenings
health promoting activities
have good diet
Immunosuppressants and corticosteroid side effects with lupus
increased risk for infection
Increased risk for osteoporosis
RA patho
Immune system attacks joints causing effusion pain and edema
After triggering even subsides pannus occurs
This results in destruction of joint cartilage and bone
Pannus
Proliferation of new synovial joint tissue WITH inflammatory cells already formed
occurs due to RA
RA is autoimmune
body attack self
S/S of RA
PAIN
joint swelling
limited movement
stiffness
weakness
Diagnosing RA
Health history
Lab values
Xray
CT
MRI
Rx management of RA
salicylates (aspirin)
NSAIDs
DMARDs (work on autoimmune response)
None Rx management of RA
Heat/Paraffin baths 20 min max
Therapeutic exercises
Braces, splints, assistive devices (canes)
Treatment goals for RA
v inflammation
control pain
^ mobility
^ PT knowledge
RA exercise and activity
Physical/occupation therapy
TENS
relaxation techniques
Sleep with RA can be aided by
Pain interferes with sleep
Low dose antidepressants
Amitriptyline
Good sleep hygiene (cold room, no tv, no eating in bed, etc.)
clues for RA problems in elderly
Gait pattern change
Guarding
Joint flexion