S2 L2 Renal Clearance and Measurement of Kidney Function

Question 1

GFR:

• What is filtration function?
• How is filtration function measured?
• What is GFR?
• Healthy amount of GFR to produce?
• 4 processes that happen in the nephron?

Answer 1

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Question 2

GFR and disease:

• A decline in GFR means…
• Why decline?
• What does it mean if the GFR is recovered?
• What changes are seen to the nephron if kidney function declines slowly?
• What do we measure as a ‘replacement’ for GFR?

Answer 2

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Question 3

Renal clearance:

• What is clearance?
• Equation involving clearance (and units)
• Caviat of this equation

Answer 3

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Question 4

The Concept of Renal Clearance:

• What do we need to consider when thinking about clearance (i.e. processes)
• Model shown - explain (don’t worry if can’t - just may help with understanding clearance!)
• What would the plasma look like - pic attached

Answer 4

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Question 5

Understanding clearnance through the following model...
(on answer side of FC)
- What is reabsorption?
- What is secretion? 
- Units of clearance

Answer 5

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Question 6

Urine flow rate:

• What is this?
• Model to show it

Answer 6

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Question 7

Fill out the table, about clearance…

Answer 7

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Question 8

Clearance of glucose:

- Work this out (think about the model)

Answer 8

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Question 9

Clearance of Albumin:

- Work this out (think about the model)

Answer 9

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Question 10

Clearance of Inulin:

• Work this out (think about the model)
• What is inulin used to measure and why?

Answer 10

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Question 11

Clearance of PAH:

• Work this out (think about the model)
• What is PAH used to measure?

Answer 11

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Question 12

Clearance of Urea:

- Work this out (think about the model)

Answer 12

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Question 13

Equations:

• What is Filtration rate
• What is clearance?
• What is excretion rate?
• What is renal plasma flow?
• What is filtration fraction

Answer 13

RPF = RBF x (1 - Hmt)

Filtration fraction = GFR/RPF