Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

(LUSUMA) Clinical Pharmacology & Therapeutics > S11) Drugs Affecting Acid Secretion > Flashcards

S11) Drugs Affecting Acid Secretion Flashcards

1
Q

What are the defensive factors for gastric mucosa?

A
  • Epithelial integrity
  • Cell replication and restitution
  • Mucous membrane barrier
  • Vascular supply
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

Which factors aggravate gastric mucosa?

A
  • Acid
  • Drugs
  • Helicobacter pylori
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

What are the stimulatory receptors on the basolateral membrane of a parietal cell?

A
  • Acetylcholine
  • Cholecystokinine B (CCK-B)
  • Histamine 2 receptor (H2)
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

The proton pump is found on the canicular membrane of the parietal cell.

How does this pump work?

A

HK ATPase exchanges H+ for K+

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

Briefly, describe some key features of proton pump inhibitor action

A
  • Delayed action – not all pumps active at a time
  • Max efficacy after 2-3 days
  • Restoration of acid secretion requires de novo synthesis
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

Briefly, illustrate the relationship between Helicobacter pylori and the following peptic ulcer disease:

  • Gastric ulcer
  • Duodenal ulcer
A
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

Identify some common drugs which can be used to treat peptic disorders

A
  • Antacids
  • Alginates
  • H2RA
  • PPI
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

What medical advice is given to the patient in ‘step one’ for treating GORD?

A
  • Weight loss
  • Decrease alcohol
  • Stop smoking
  • Smaller meals / less acidic foods
  • Antacids e.g. Gaviscon
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

What treatment is given to the patient in ‘step two’ for treating GORD?

A

H2 receptor antagonist e.g. ranitidine

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

What treatment is given to the patient in ‘step three’ for treating GORD?

A

Proton pump inhibitors e.g. omeprazole, lansoprazole, esomeprazole

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

What are the side effects of proton pump inhibitors?

A
  • Diarrhoea
  • Osteoporosis (with long term use)
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

What investigation should one perform if a patient presents with any red flags for GORD?

A

Urgent upper GI endoscopy – ulcers, malignancy, hiatus hernia

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

What is Helicobacter pylori?

A
  • H.pylori is a gram negative bacteria found in the GI tract, which can cause gastric and duodenal inflammation / ulceration
  • It is toxic to epithelial cells / degrades mucosal lining
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

How do we test for H.pylori?

A
  • Carbon-13 urea breath test
  • Stool antigen test
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

How do we eradicate H.pylori?

A

Triple therapy for 1 week:

  • Clarithromycin 500mg BD
  • Amoxycillin 1g BD
  • Lansoprazole 30mg BD
How well did you know this?
1
Not at all
2
3
4
5
Perfectly

(LUSUMA) Clinical Pharmacology & Therapeutics (29 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions