Rx Onc

Question 1

HNPCC (Lynch Syndrome) assoc risks?

Answer 1

70% = colorectal cancer by 40-45 yo

high risk of endometrium, ovary, UT, SI, stomach and biliary cancer

Question 2

Bx Medulloblastoma

Answer 2

deeply staining nuclei with scant cytoplasm arranged in pseudorosettes that form sheets of anaplastic cells, small cells, crescent-shapped

HOMER WRIGHT ROSETTES (pseudorosettes)
arranged concentrically around a central space filled with neurophil (lumen = rosette)

Question 3

Clinical Findings medulloblastoma

Answer 3

cerebellar signs = nystagmus, trucal ataxia, clumsy

incr IC pressure = vomiting, headache

Question 4

findings on fundoscopic exam of Rb mutation

Answer 4

amelanotic large endophytic mass in inferior pole of retina