Rx Heme Flashcards
Immune Thrombocytopenic purpura blood smear, bone marrow, presentation
nl PLT, maybe bigger
more megakaryocytes in the marrow
easy bruising, bleeding, anti-PLT antibodies, low PLT count
Drepanocytes
sickled RBCs
Howell-Jolly bodies
retained chromosomes in RBCs of pts who have undergone splenectomy
Pappenheimer bodies
Siderosomes = iron bodies seen on Wright stain of RBCs in pt with excess iron
complication later in life of hereditary spherocytosis
unconjugated bilirubin gallstones (less soluble) and cholecystitis,
confirm Dx of hereditary spherocytosis
osmotic fragility test
findings of hereditary sperocytosis
spherocytes -> defect in spectrin protein
incr mean corpuscular HgB concentration
small round red cells with no central pallor
tx of hodgkin lymphoma
ABVD regimen
Adriamycin (doxorubicin), Bleomycin, Vinblastine, Dacarbazine
complications of Sickle Cell
episodic hematuria and impaired urine concentration b/c microscopic thromboembolic events w/i renal medulla
mutation in Factor V Leiden
resistance to decactivation of factor V by protein C -> hypercoagulable state -> predisposed to DVT and PE
Pathology of Multiple Myeloma
high levels of IgG light chain fragments can form B-pleated sheets of AL protein
congo red stain appears bright apple green color w/ polarized light
Clinical Findings of Multiple Myeloma
lytic bone lesions (can cause fractures and hypercalcemia) and renal disease (Bence-Jones casts, nephrocalcinosis, metastatic involvement of kidney, and amyloidosis)
peripheral smear of Multiple Myeloma
single file stacking of RBCs = rouleaux formation
seen in 50% of MM cases and other dz that cause increased serum protein
Blood smear of acute promyelocytic leukemia
Auer rods (large WBC with azurophilic granular needles in cytoplasm)
Tx of APL
all-trans retinoic acid -> promotes differentiation of immature cells
