Rx Drugs ADR

Question 1

NRTI/Zidovudine

Answer 1

bone marrow suppression (neutropenia, anemia), peripheral neuropathy, and lactic acidosis
Zidovudine = only NRTI with megaloblastic anemia

Question 2

Serotonin Syndrome - drugs that can cause

Answer 2

Depression pt (SSRI) + MAOI, certain opioids, TCAs, psychedelics, CNS stimulants.

Question 3

Serotonin Syndrome presentation

Answer 3

agitation, ataxia, diarrhea, diaphoresis, mental status changes, hyperthermia, muscle rigidity
(5HT R in GI, vasculature, brainstem raphe nuclei)

Question 4

Heparin

Answer 4

bleeding, HIT, osteoporosis

Question 5

HIT

Answer 5

IgG against PLT factor 4 -> activates PLT -> thrombosis and thrombocytopenia -> intravascular thrombosis

Question 6

HIT type 2

Answer 6

4-5 days after heparin

PLT

Question 7

Amantidine for Influenza Type A

Answer 7

ataxia, slurred speech, dizziness, jitteriness, insomnia

Question 8

Vinblastine

Answer 8

alopecia, constipation, myelosuppression (vinBLASTS the bones)

Question 9

Gentamicin

Answer 9

Aminoglycosides = ototoxicity (ringing in ears, hearing loss = cochlear; or vestibular = vertigo, N/V, ataxia); nephrotoxicity and nonoliguric acute tubular necrosis

Question 10

HIPPES have lupus

= drugs that cause lupus like syndrome

Answer 10

Hydralazine, INH, Procainamide, Phenytoin, Etanercept, Sulfa drugs

Question 11

What drugs are contraindicated with asthma

Answer 11

B-blockers
B1 selective -> careful monitoring but can be used (usu. A-M olol)
Nonselective B-antag -> mostly N-Z olol (B2 with 2nd half of alphabet)

Question 12

Drugs assoc with gynecomastia

Answer 12

imbalance of estrogen to testosterone
Cimetidine/Ranitidine (H2 receptor antag)
CV drugs = spironolactone, digitalis CCB, ACEi
Omeprazole (PPI)

Question 13

How do Cimetidine/Ranitidine cause gynecomastia

Answer 13

b/c inhib CyP450 (slows breakdown of estradiol)