Rx Files Men's Health Flashcards
1
Q
Define ED
A
inability to achieve or sustain an erection
2
Q
What is on the differential diagnosis as to the cause of ED?
A
- cardiovascular disease
- diabetes
- ethanol/ substance abuse
- psychological factors
3
Q
What drugs may cause ED?
A
- antipsychotics
- antidepressants
- propranolol
4
Q
Sildenafil brand
A
Viagra
5
Q
Sildenafil mechanism of action
A
selective PDE-5 inhibitor
6
Q
Sildenafil dosing
A
50 mg (25 mg for elderly) one hour prior to intercourse. Max dose 100 mg/day
7
Q
Sildenafil ADRs
A
- headache
- flushing
- priapism
8
Q
What may happen with high sildenafil levels?
A
PDE-6 may be affected which plays a role in photo-transduction in the retina - patient may complain of blue-tinted vision
9
Q
What is a serious drug interaction with sildenafil?
A
Nitrates can cause fatal hypotension
10
Q
What is the difference between sildenafil and newer analogues?
A
greater selectivity for PDE-5 with longer half life