Rx Files CCBs Flashcards
Primary uses of CCBs
angina
select arrhythmias
HTN
What are the types of Ca channels?
L, T, N, P
How are CCBs eliminated?
hepatically metabolized
nifedipine brand
Adalat
Adalat CC
Procardia
Procardia XL
Nifedipine chemical class
dihydropyridines
Nifedipine adverse effects
- flushing/ rash
- peripheral edema
- dizziness
- gingival hyperplasia
Nifedipine onset of action
PO 20 minutes
SL 1-5 minutes
Nifedipine dosage
IR: 10 mg PO TID
SR: 30 - 90 mg PO daily
Adalat CC should be taken on (full/empty) stomach.
empty
Counselling point on nifedipine SR formulations
SR tablet cores may appear in stool
Diltiazem brand
Cardizem CD Cardizem Dilacor Dilacor XR Tiamate Tiazac
Diltiazem prolongs (AV/SA) conduction.
AV
Diltiazem chemical class
benzothiazepine
Diltiazem dosage forms
IV
PO
What is diltiazem IV most commonly used to treat?
atrial fibrilation
Diltiazem adverse effects
- bradycardia
- AV block
- peripheral edema
- flushing
Diltiazem IV dosage
bolus: 0.25 mg/kg over 2 minutes
infusion: 10 mg/hr
Diltiazem IV to PO
Use IR PO dosage form and overlap by about 3 hours
Why should diltiazem be used cautiously in CHF?
strong negative inotrope
Verapamil brand
Calan Calan SR Covera HS Isoptin Isoptin SR Verelan
Verapamil chemical class
phenylalkylamine
Verapamil prolongs (AV/SA) node conduction
AV
Verapamil should be used cautiously in patients with (tachy/brady)cardia.
bradycardia
Verapamil adverse reactions
- hypotension
- CHF
- peripheral edema
- constipation
(T/F) Verapamil is available as IV.
True
Verapamil dosage
IR: 80 - 120 mg PO TID
Amlodipine brand
Norvasc
Amlodipine chemical class
dihydropyridine
Amlodipine adverse effects
- peripheral edema
- flushing
What is the favorable characteristic of amlodipine?
daily dosing
Amlodipine dosage
5-10 mg PO QD
Amlodipine is particularly selective for (myocardium/vasculature).
vasculature
Nimodipine brand
Nimotop
Bepridil
Vascor
Felodipine
Plendil
Nicardipine
Cardene
Nisoldipine
Sular
Nitrendipine
Cardif
Nitrepin
Lacidipine
Motens
Lercanidipine
Zanidip