RVT- Neoplastic Drugs Flashcards
What are the characteristics of neoplastic cells that anti cancer drugs act on?
Rapidly growing and dividing cells-
Different rate of drug intake
Increased cellular response
At what phase in the cell cycle are the enzymes needed for DNA synthesis produced?
G1
What are non-specific cell cycle drugs?
Drugs that don’t work to act within a specific cycle in the cell life
What are specific cell cycle drugs?
Drugs that work within a specific cell phase
G1, S, G2, Mitosis
Do anti-cancer drugs work best on high or low growth fraction cells?
High growth fraction cells
What are examples of cancers with high growth fraction cells?
Leukaemia and some lymphomas
What are the characteristics of high growth fraction cells?
Small, fast growing, early forming
What are the characteristics of low growth fraction cancers?
Solid tumours, cells in G0 ( rest) phase of cell cycle
What are the 4 classes of neoplastic drugs?
Anti tumour antibiotics
Anti metabolic drugs
Alkaloids
Alkalating drugs
How are neoplastic drug calculations different that regular drug calculations?
Dosed according to body surface area = m2
Before and after neoplastic drug administration, what important steps must be taken?
Flushing of catheter with saline to assure equipment is correct. Important not to have any drug outside of the blood vessel
What are the two methods of neoplastic drug administration?
Combination therapy and pulse dosing
What are the anti tumour antibiotic drugs derivatives of?
Streptomyces
What are the 4 drugs in the anti tumour antibiotic class?
Doxorubicin
Actinomycin
Mitoxanthrone
Streptomyces
How do anti tumour antibiotics work?
Initiate free radical formation
Inhibit an enzyme involved in DNA synthesis= DNA fragmentation
No enzyme=no DNA