RUSVM Physio Neuro Part 3

Question 1

T/F ependymal cells form a selective tight-junction barrier

Answer 1

True

Question 2

Where is most of the CSF formed?

Answer 2

at the choroid plexus of the ventricles.

Question 3

What is the choroid plexus joined by?

Answer 3

Tight junctions

Question 4

T/F CNS Accounts for 20% of the body weight but has disproportionately high metabolic rate and receives 2% of the total cardiac output

Answer 4

False- CNS = 2% body weight and receives 20% of total cardiac output.

Question 5

What ventricle is oriented longitudinally in each hemisphere and connected with the 3rd ventricle

Answer 5

Lateral ventricles

Question 6

What forms a perivascular end feet around the entire outer surface of the capillary endothelium?

Answer 6

Astrocytes

Question 7

What ventricle is connected with the subarachnoid space?

Answer 7

4th ventricle

Question 8

The BBB is highly permeable to what?

Answer 8

water, CO2, O2 and most lipid soluble substances such as OH and anesthetics

Question 9

Where is the blood CSF barrier and BBB located

Answer 9

Located both at the choroid plexus and at the tissue capillary membranes in all areas of the brain.

Question 10

T/F Interaction between astrocytes and endothelial cells is important for the maintenance of the BBB

Answer 10

True

Question 11

How is the manner in which the cells are joined together in the BBB

Answer 11

Membranes of the adjacent endothelial cells are tightly fused rather than having large slit pores between them

Question 12

Most of the CSF is absorbed from the subarachnoid space into the venous sinuses through what?

Answer 12

Arachnoid villi

Question 13

What causes the low permeability of the barrier ?

Answer 13

The manner in which the cells are joined to one another.

Question 14

What contains CSF?

Answer 14

the ventricular system and the subarachnoid space. CSF is also in the central canal that runs through the core of the spinal cord.

Question 15

T/F Absorption of CSF appears to be pressure independent and multidirectional

Answer 15

False- pressure DEPENDENT and UNIdirectional

Question 16

What ventricle surrounds the interthalamic adhesion and connected with the 4th ventricle

Answer 16

3rd ventricle

Question 17

The neuraxis and meninges are drained by what?

Answer 17

veins and sinuses

Question 18

What glucose transporter is used in the BBB

Answer 18

GLUT 1

Question 19

White or Grey matter receives more blood?

Answer 19

Grey matter receives more blood than white matter.

Question 20

What is the BBB slightly permeable too?

Answer 20

to electrolytes such as Na, Chloride and K.

Question 21

What are the functions of the CSF

Answer 21

• Cushion the brain, protection against hard blows
• Maintain a consistent extracellular microenviornment for the neurons and glia
• effective waste control system that can remove potentially harmful cellular metabolites
• Act as a brain distribution system for some peptide hormones and growth factors.

Question 22

What is the BBB almost totally impermeable too?

Answer 22

Plasma proteins and non-lipid-soluble large organic molecules.

Question 23

The ventricular system comprises 4 expanded regions forming ventricles interconnecting what?

Answer 23

Foramens and tubes

Question 24

What cells cover the choroid plexus?

Answer 24

thin layer of ependymal cells (glial cell)