Rubraca- Intro to prostate cancer Flashcards
The prostate surrounds which anatomic structure?
Urethra
Most cancers arise in which portion of the prostate?
Peripheral
The fluid secreted by the prostate adjusts what properties of semen?
Viscosity and acidity
PSA increases in what setting(s)?
Prostate cancer, BPH, Prostatitis
Approximately what percentage of men with prostate cancer in the US have metastatic disease?
4%
Which of the following risk factors is well established for the development of prostate cancer?
Increasing age
The USPSTF recommends shared decision-making about PSA screening for men of average risk in what age group?
55-69
What is the most common initial metastatic site of prostate cancer?
Bone
What is the primary source of testosterone production in healthy men?
Testicles
What substance does the hypothalamus secrete to ultimately stimulate testosterone production?
GnRH
What process does the AR undergo in a prostate cell after binding to an androgen?
Nuclear translocation
Which of the following enzymes is important in androgen synthesis from precursor molecules?
CYP17
Rising PSA after definitive local therapy signals what?
Biochemical recurrence
A Gleason pattern of 4 + 3 indicates what?
Gleason score of 7, grade group 3
A PSADT of what duration is associated with an increased risk of metastasis and mortality?
<3 months
What does TNM stand for in PC disease stagings?
Tumor, Node, Metastasis
