Rosh Material #3 Flashcards
primary PTX mc occurs in what pt pop
tall, thin boys
men aged 10-30 yo
what do you think when you see: abrupt onset of SOB, decreased chest excursion, diminished breath sounds, decreased tactile fremitus
PTX
what do you think when you see: hypotension, tachycardia, mediastinal/tracheal shift
tension PTX
what do you think when you see: visceral pleural line that can be seen only on expiratory films
PTX
increased radiolucent costophrenic sulcus on CXR
contralateral shift in the mediastinum
deep sulcus sign → PTX
order of tx for PTX based on severity
- obs and O2
- simple drainage w. small bore catheter
- small bore chest tube
- chest tube w. suction
which PTX require chest tube w. suction
large PTX
tension PTX
secondary PTX
severe sx
tx for recurrent PTX
thoracoscopy
OR
open thoracotomy
4 types of PTX
spontaneous → primary (tall, thin men) vs secondary (chronic dz)
iatrogenic
traumatic
catamenial → result of thoracic endometriosis
what drug is used for prevention of pneumocystis PNA
bactrim
what do you think when you see: HA, aquagenic pruritis, ruddy facial plethora, palpable splenomegaly, erythromalagia
polycythemia vera
leading cause of death in polycythemia vera pt
thrombosis
what gene mutation is associated w. polycythemia vera
JAK2
complications of polycythemia vera
malignancy
myelogibrosis
AML
myelodysplastic syndrome
tx for polycythemia vera
- phlebotomies to maintain Hct <45
- low dose ASA
- cytoreductive therapy for high risk → hydroxyurea or interferon
- anticoagulation
bone marrow bx findings of: hypercellularity for age w. trilineage growth (panmyelosis), prominent erythroid, granulocytic, and megakaryocytic proliferation w. pleomorphic mature megakaryocytes
polycythemia vera
pruritis following a warm bath or shower
polycythemia vera
what is Budd Chiari syndrome
disorder that occurs when the hepatic venous outflow is obstructed dt a thrombus w.in a hepatic vein
what do you think when you see: pallor, jaundice, dark urine, anemia, hepatosplenomegaly
beta thalassemia major
iron storage disorder in which iron absorption is increased and stored as hemosiderin in the liver, heart, pancreas, pituitary testes, kidneys and adrenals
hereditary hemochromatosis
sx of hereditary hemochromatosis
fatigue
arthralgia
arthropathy
hepatomegaly
skin pigmentation
hepatic dysfxn
cardiac enlargement/failure
DM
ED
liver bx showing Prussian blue stain
hereditary hemochromatosis
→ due to intense iron stores in the liver
how much etch intake/day increases risk of developing cirrhosis
>30 grams
how much etch intake/day increases risk of developing cirrhosis
>30 grams
dx for hereditary hemochromatosis
MRI
OR
liver bx
also HFT genotype
which DM med has been shown to lower A1C levels and reduce the risk of CVD in adults w. T2DM
empagliflozin
pneumococcal vaccine is recommended for what 2 pt pops
adults 65 or older
adults < 65 w. rf
mc s.e of isoniazid
peripheral neuropathy
hepatitis
rash
mild CNS
mc s.e of rifampin
hepatitis
flu like
GI bleed
kidney failure
mc s.e of Pyrazinamide
hyperuricemia
hepatotoxic
rashGI
joint aches
mc s.e of ethambutol
optic neuritis
mc s.e of streptomycin
CN VIII damage
nephrotoxic
how many mm of induration will be present on a pt w. HIV and TB who undergoes TB skin test
5 or more
6 p’s of acute arterial embolism
paresthesia
pain
pallor
pulselessness
paralysis
poikilothermia
childhood condition that is most acute
follows viral infxn
sx include: petechiae, gingival bleeding, epistaxis, menorrhagia, GI bleeding, intracranial hemorrhage
immune thrombocytopenia of childhood
management of immune thrombocytopenia of childhood
supportive
platelets
corticosteroids
IVIG or anti-D immunoglobulin
splenectomy
emergent care if severe sx (ex GI bleeding)
labs associated w. immune thrombocytopenia of childhood
isolate thrombocytopenia w. normal Hgb, Hct, and WBC
platelet count < 100,000
autoantibodies associated w. immune thrombocytopenia of childhood
glycoprotein IIb/IIIA complex
what steroid sparing agents are appropriate for chronic immune thrombocytopenia in children
rituximab
thrombopoietin receptor agonists (romiplostim, eltrombopag)
azathioprine
mycophenolate mofetil
meds that commonly cause pill esophagitis
abx
NSAIDs
bisphosphonates
KCl
quinidine
vitamin C
iron
3 abx that commonly cause pill esophagitis
tetracyclines
bactrim
clindamycin
gradually progressive dysphagia to solids
can be due to GERD, pt’s undergoing xrt, eosinophilic esophagitis
esophageal stricture
first line tx for benign esophageal strictures
esophageal dilation
2 mc presenting sx of colorectal ca
painless hematochezia
change in bowel habits
bowel obstruction and change in bowel habits are mc with __ sided colorectal ca
left
hematochezia and IDA are mc seen w. __ sided colorectal ca
right
what does “apple core lesion” make you think of
circumferential colorectal carcinoma
anemias w. low MCV
IDA
sideroblastic
thalassemia
anemia of chronic dz
anemias w. high MCV
B12/megaloblastic/pernicious
what does basophilic stipling make you think of
lead poisoning
thalassemias
etch
heavy metal poisoning
only anemia associated w. increased TIBC
iron deficiency anemia
mc cause of large bowel obstruction in older pt
neoplasm
mc cause of PUD
h pylori
NSAIDs
duodenal ulcers affect what pt pop
gastric ulcers affect what pt pop
duodenal: young
gastric: older
gs dx for peptic ulcers
endoscopy
gs testing for h. pylori
urea breath test
fecal antigen assay
serology
quadruple therapy for h. pylori
bismuth
metronidazole
tetracycline
omeprazole
areas of macrolide resistance
triple therapy for h. pylori
omeprazole
clarithromycin
amoxicillin
metronidazole if pcn allergy
most sensitive test for h. pylori
urea breath
where in the stomach are the most benign ulcers found
antrum
chronic insomnia is defined as
sx at least 3x/week for at least 3 months
first line tx for insomnia
CBT
when would you order polysomnography for insomnia
cases where organic cause is suspected
ex OSA
pharm for insomnia
benzos
non benzo receptor agonists
sedatives
melatonin agonists
suvorexant
antipsychotics
2 mc relaxation based strategies for insomnia d.o
progressive muscle relaxation
diaphragmatic breathing
pt takes a deep breath while examiner palpates upward in area of gallbladder fossa
murphy sign
cholecystitis PLUS elevated bilirubin and alk phos is concerning for (4)
biliary obstruction
cholangitis
choledocholithiasis
mirizzi syndrome
order of dx tests for cholecystitis
- US
- cholescintigraphy (HIDA) → if dx unclear
- CT
preferred definitive tx for cholecystitis
cholecystectomy
test to order for cholecystitis with coexisting elevated bilirubin, elevated liver enzymes, or e.o bile duct dilation on US
MRCP (magnetic resonance cholangiopancreatography)
to r.o choledocholithiasis
what is Charcot triad
jaundice
fever
RUQ pain
hyperesthesia, increased or altered sensitivity below the right scapula
boas sign → cholecystitis
painful linear tear in the anal canal
anal fissure
causes of anal fissure
low fiber diet
passage of hard or large stools
anal trauma
what do you think when you see “severely painful BM and bright red blood per rectum during BM”
anal fissure
primary anal fissures are located __
and caused by __ (6)
posterior midline
local trauma, constipation, diarrhea, vaginal delivery, anal intercourse
lateral anal fissures are located __
and caused by __
lateral
Crohn dz, granulomatous dz, malignancy, communicable dz
management of anal fissures
topical nifedipine or nitroglycerin
topical analgesic
stool softener
sitz bath
fiber
what do you think when you see “erythematous ulcer on anal margin”
Crohn dz
what do you think when you see: “perineal induration” accompanied by erythema, fever, drainage
anorectal abscess
what do you think when you see: “tender palpable mass on anal margin” and rectal bleeding
external hemorrhoids
less painful than anal fissure
if anal fissures are located __,
search for pathologic etiologies
laterally
what is second-line tx for persistent anal fissures
topical nitroglycerin or nifedipine ointment
mc type of lung ca
not associated w. smoking
adenocarcinoma
acute purulent inflammation of the eyelid
mc at or near eyelash follicle
hordeolum (stye)
mc cause of hordeolum
staph aureus
tx for hodeolum
warm compress
abx are rarely effective
blocked oil gland on eyelid
mc found above eyelashes on upper lid
firm, painless
chalazion
tx for chalazion
warm compress
steroid injxn
surgery
diffuse eyelid inflammation
often associated w. rosacea or seborrhea dermatitis
blepharitis
sudden and rapid rise in intraocular pressure
acute angle closure glaucoma
classification finding on fluorescein stain for HSV keratitis
dendritic branches
what is this showing
basal cell carcinoma
slow growing
waxy/pearly nodule
rolled borders
telangiectasias
basal cell carcinoma
tx for basal cell carcinoma
topical imiquimod
5 fluoracil
curettage and electrodessication
excision
mohs micrographic sx
which tx for skin ca has the highest cure rate and results in least amount of tissue loss
mohs micrographic sx
painless, firm, shiny, flesh colored or bluish-red nodule on sun exposed area
rarely has ulceration or crusting
merckle cell carcinoma
non healing ulcers/warty nodules
may crust or bleed
common in pt who sunburn easily
squamous cell carcinoma
which type of Hodgkin lymphoma is mc
non-hodgkin
what pathogen mc causes prostatitis in men > 35 yo
e.coli
also: proteus, enterobacteriaceae, pseudomonas
fever, urinary retention, irritation w. voiding, fever
warm, edematous, exquisitely tender prostate
often in setting of recent urinary catheter
prostatitis
tx for prostatitis
bactrim
fluoroquinolone
x 4-6 weeks
pathogens associated w. prostatitis in men < 35 yo
Neisseria gonorrhoeae
chlamydia trachoma’s
tx for prostatitis associated w. STI
ceftriaxone
doxycycline
uniform, enlarged, firm prostate w. a palpable median sulcus
BPH
what class of med is recommended in the initial tx for symptomatic prostatic hyperplasia
alpha-1 adrenergic antagonists → tamsulosin, terazosin
avoid what tx for prostatitis
vigorous prostatic massage
what type of bacteria is associated w. struvite stones
proteus mirabilis
urease producing bacteria → magnesium phosphate crystals
what do you think when you see: pyuria and WBC casts
pyelonephritis
imaging of choice for pyelo
abd/pelvis CT
what do you think when you see: f/c, recent UTI, flank pain, CVA tenderness, n/v
pyelonephritis
mc bacteria associated w. acute pyelonephritis
e.coli
proteus mirabilis
klebsiella
staph
op management for pyelonephritis
cipro, levo
OR
bactrim
inpt tx for moderate pyelonephritis
ceftriaxone
OR
cipro/levo
inpt tx for severe pyelonephritis
cefepime
OR
zosyn
OR
meropenem
how many colony forming unites of a single organism on urine culture are suggestive of UTI
100,000
mc pathogens associated w. acute bronchitis
influenza A and B
parainfluenza
coronavirus
rhinovirus
RSV
bacterial causes of acute bronchitis
mortadella pertussis
mycoplasma pneumoniae
chlamydia pneumoniae
sx of acute bronchitis
cough lasting 5 days or more
purulent or non purulent d.c
+/- preceding URI
widening of bronchioles d.t chronic infxn
persistent cough w, mucopurulent sputum
recurrent lung infxns
hemoptysis
bronchiectasis
differentiating factor between bronchitis and PNA
f/c
anorexia
abnormal vitals
lung consolidations on CXR
what is the name of the pulmonary PE test performed by placing the ulnar aspects of both hands agains the pt’s chest while pt says “99”
tactile fremitus
mc location for disc herniation
L4-5
L5-S1
test to order if you suspect cauda equina
MRI
2 mc surgical procedures for lumbar radiculopathy
open discectomy
microdiscectomy
pain down the back of the leg is associated w. which myotome
S1