ROS Flashcards
1
Q
Give 5 examples of ROS
A
hydrogen peroxide, superoxide, hydrogen radicals and peroxynitrite and hydrochlorous acid
2
Q
How is ROS formed in the body
A
1- mitochondria during aerobic respiration
2- NADPH oxidase NOX formation to kill phagocytosed bacteria 3- metabolism of long chain fatty acids in peroxisomes produce ROS as a byproduct 4- radiation or other toxic exposure
3
Q
What is the half life of ROS’ and why is it significant
A
Have a short half life so do not travel far to exert damage
4
Q
What will ROS exposure lead it
A
Can oxidize protein (aggregations), DNA (mutations), lipids (PM damage), and also CHOs
5
Q
What are some of the protective mechanisms against peroxidases?
A
SODS, catalyses, peroxidases, vitamin E, beta-carotene and ascorbic acid
