Role of NF-kB in inflammation and atherosclerosis

Question 1

NF-kB Activation

Answer 1

• IL-1 activates IL-1R
• Cascade activates Inhibitor of kB Kinase (IKK)
• IKK Pi IkB, IkB degrades
• NF-kB disinhibited

Question 2

NF-kB mechanism (inflammatory molecules and chemokines)

Answer 2

• Promotes expression of IL-1, IL-6, TNF-a

- Promotes expression of MCP-1 and ICAM-1

Question 3

NF-kB and apoptosis

Answer 3

• Fas death pathway depends on NF-kB

Question 4

Regulation

Answer 4

• Liver X enzyme may recruit coregulatory proteins to reduce transcription of immune response genes