Leukocyte Adhesion

Question 1

Main Stages of Adhesion

Answer 1

1. Capture
2. Rolling
3. Slow Rolling (activation)
4. Firm Adhesion (intraluminal crawling)
5. Transmigration

Question 2

Phase 1

Receptor (distribution)-Ligand examples

Answer 2

Capture: Selectins

E-Selectin (ECs activated by TNF, IL-1): Sialyl-Lewis X, related glycans (CLA-1)

P-Selectin (Storage granules, EC and Pl surface membrane): SLEx PSGL-1

Question 3

Phase 2

Answer 3

Rolling: Integrins