Robbins 25

Question 1

3 layers of skin

Answer 1

1. Epidermis: keratinocytes (squamous epithelial cells)
2. Dermis: CT/vessels
3. SubQ fat (hypodermis or subcutis)

Question 2

5 layers of epidermis

Answer 2

Come, Let’s Get Sun Burned

1. Stratum corneum
2. Stratum lucidum
3. Stratum granulosum
4. Stratum spinosum
5. Stratum basale

Question 3

Stratum Corneum

Answer 3

• Keratinized dead anucleated cells
• Fill with keratin filaments

Question 4

What is stratum lucidum

Answer 4

Clear layer of dead skin cells only found in:

• 1. lips
• 2. palms
• 3. soles of feet

Question 5

What is stratum granulosum?

Answer 5

Keratohyalin granules that form keratin filaments

Question 6

Stratum spinosum

Answer 6

Desmosomes that form spines

Question 7

What is stratum basalis

Answer 7

Single layer of cuboidal stem cells in contact with basement membrane: keratinocytes and melanocytes

Question 8

What is used in pathology to ID keratinocytes?

Answer 8

Ab to various cytokeratins

Question 9

What type of cells are epidermis of skin?

Answer 9

Stratified squamous epithelium

Question 10

What does the dermis of the skin contain?

Answer 10

1. BV,
2. Nerves,
3. Adnexa (hair follicles + sebaceous glands + sweat glands/apocrine and eccrine glands.

Question 11

What are skin adnexa (appendages)?

Answer 11

Structures derived from skin and adjacent to it. Includes

1. Hair follicles
2. Sebaceous glands
3. Sweat glands

Question 12

Keratinocytes are found in what layer of the skin?

Answer 12

Basal layer of skin

Question 13

Where are melanocytes located?

What are they?

Answer 13

• Basal layer of epidermis
• Specialized secretory cells derived from NC that make melanin (in melanosomes)
• Melanosomes are then transferred to keratinocytes