First Aid: Pathologic RBC forms Flashcards
1
Q
Disorders you see Macro-ovalocytes in
A
- Megablastic anemias (Vit B12/ folate deficiency) + hypersegmented neutrophils/PMNs
2
Q
Disorders you see Schistocytes/Helmet cells in
A
- Microangiopathic Hemolytic Anemia (DIC, TTP, HUS, HELLP syndrome and mechanical hemolysis): fragmented RBC
3
Q
Disorders you see Spherocytes in
A
Small, spherical cells without central pallor
- Hereditary spherocytosis
- AIHA
- Drugs and infection-induced hemolytic anemias
4
Q
Disorders you see Target cells in
A
HALT: said the Hunter to his target!
- HbC disease
- Asplenia
- Liver disease
- Thalassemia
5
Q
Disorders you see Basophilic Stippling in
A
Aggregation of RNA precipitate
- Thalassemias
- Sideroblastic anemias (lead poisoning + myelodysplastic syndromes) Aggregation of RNA precipitate
6
Q
Disorders you see Schistocytes/Helmet cells in
A
- Microangiopathic Hemolytic Anemia (DIC, TTP, HUS, HELLP syndrome and mechanical hemolysis): fragmented RBC
7
Q
Disorders you see Heinz bodise in
A
G6PD deficieny: preciptiation of Hb due to oxidative stress. When phagocytes remove Heinz bodies => forms a bite cell
8
Q
Howell Jolly bodies
A
Functional hyposplenia or asplenia (hereditary spherocytosis and sickle cell anemia)
