RNA viruses - Naked, +ssRNA viruses - Picornaviridae - Hepatoviruses Flashcards by A E | Brainscape

Q

What is the causative agent of Hepatitis A?

A

Hepatitis A virus

Genus Hepatovirus

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Q

Characteristics of Hepatitis A virus

A

Survives on various surfaces
Resistant to common household disinfectants
pH 1
60 C
In water for months

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Q

Transmission of Hepatitis A virus

A

The Fecal-oral route:
Contaminated food (shellfish) or water
Binds to TIM-1, expressed by T-cells and hepatocytes
Asymptomatic children patients release viruses in feces through bile

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Q

Signs and Symptoms of Hepatitis A virus

A

Due to the patient’s own immune response (Cytotoxic T lymphocytes, NK cells, Abs, C).
The virus is not Cytolytic
Infections DOES NOT cause chronic liver disease or cancer
Complete recovery occurs most of the time

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Q

Diagnosis of Hepatitis A virus

A

Serologic tests, anti-HAV IgM

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Q

Prevention

A

Vaccine is available for children and adults

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