RNA viruses - Naked, +ssRNA viruses - Picornaviridae - Rhinoviruses

Question 1

Talk about Rhinoviruses

Answer 1

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Question 2

What are the common cause of Rhinovirus?

Answer 2

The common cold

Question 3

What is the epidemiolopgy of Rhinovirus infections?

Answer 3

1) Causes most cases of the common cold

- Over 100 serotypes

Question 4

Which other virsues also causes the common cold?

Answer 4

1) Adenoviruses
2) Coronaviruses
3) Reoviruses
4) Paramyxoviruses

Question 5

Epidemiology of Rhinovirus infections

Answer 5

1) Infections is limited to the UPPER RESPIRATORY TRACT (<33C)
2) A single virus is often sufficient to cause a cold: enters through nose, mouth, eyes
3) ICAM-1 is the receptor. infected cells release histamine and brdykinin : “runny nose”+ rhinorrhea. Cytokines -> ICAM-1
4) Transmission of the virus: Aerosol, formites, or hand to hand contact
- viable for hours outside the body. Asymptomatic persons
- most commonly transmitted by direct person-to-person contact
5) People acquire some immunity against serotypes that have infected them
- The number of infections tends to dedcrease with age
- Herd immunity in isolated populations
- BUT: Mutations, new serotypes, poorly persistent humoral response

Question 6

Where are the infections of Rhinovirus ?

Answer 6

Infections is limited to the UPPER RESPIRATORY TRACT (<33C)

Question 7

How does the virus cause a cold?

Answer 7

A single virus is often sufficient to cause a cold: enters through nose, mouth, eyes

Question 8

What is the receptor involved in Rhinorrhea?

Answer 8

ICAM-1 is the receptor. infected cells release histamine and brdykinin : “runny nose”+ rhinorrhea. Cytokines -> ICAM-1

Question 9

How is the rhinovirus transmitted?

Answer 9

Transmission of the virus: Aerosol, formites, or hand to hand contact

• viable for hours outside the body. Asymptomatic persons
• most commonly transmitted by direct person-to-person contact

Question 10

How does immunity go against Rhinoviruses ?

Answer 10

People acquire some immunity against serotypes that have infected them

• The number of infections tends to dedcrease with age
• Herd immunity in isolated populations
• BUT: Mutations, new serotypes, poorly persistent humoral response

Question 11

Diagnosis of Rhinoviruses

Answer 11

Manifestations of rhinoviruses are usually diagnostic

Question 12

Treatment of Rhinoviruses

Answer 12

1) PLECONARIL can reduce the severity and duration of colds
- Must be taken at the onset if symptoms
2) Other medications can help relieve the symptoms: Antihistamines, decongestants, pain relievers

Question 13

Prevention of Rhinoviruses

Answer 13

1) Antosepsis: Handwashing is the most important preventive measure
2) No common antigens, thus no vaccine is available