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Virology > RNA viruses > Flashcards

RNA viruses Flashcards

1
Q

All RNA viruses have SINGLE strand RNA except

A

Reovirus (rota)

Naked and with segments

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2
Q

All RNA virus replicates in the cytoplasm, except 2

Nuclear IREa

A

Influenza

Retrovirus

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3
Q

Picornaviridae

EnteroPico on a PERCH

A 
P. Polio
E. Echo
R. Rhino
C. Coxsackie
H. HAV
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4
Q

Poliovirus site of replication

A

Motor neurons in anterior horn of spinal cord, causing flaccid paralysis

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5
Q

3 enteroviruses

A

Polio
Echo
Coxsackie

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6
Q
  1. Fever, sore throat and tender vesicles on posterior oropharynx
  2. vesicles on mouth, hands, and feet
A

CMV

  1. Herpangina -coxSUCKie
  2. FMD - coxSACKie
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7
Q

Only picornaviridae virus transmitted by droplet

Killed by gastric acid when swallowed

A

Rhinoviridae

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8
Q

Aka enterovirus 72

A

Hepa A virus

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9
Q

Family of Hepa E and Norwalk virus

A

Caliciviridae

Call don HeN

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10
Q

Influenza envelope:

Binds to cell surface receptor to initiate infection

A

Hemagglutinins binds to

Neuraminic adic, sialic acid

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11
Q

Influenza envelope:

Cleaves neuraminic acid (sialic acid) to release progency virus from infected cells

A

Neuraminidase

Also degrades protective mucus, enhancing access to RT

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12
Q

Antigenic shift

Reassortment of HA and NA with animal strains

A

Influenza A = pandemics

Humans: H1-3, N1-2

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13
Q 
Antigenic drift (mutations)
No animal source of new RNA segment
A

Influenza B = epidemic

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14
Q

Post-influenza complications (2)

Respi and autoimmune

A

Staph pneumonia

Reye’s syndrome if tx with aspirin

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15
Q

DOC InfluenZa

TamA Zana

A

Oseltamivir (Tamiflu) and Zanamivir (neuraminidase inhibitors)
Amantadine inhibit replication of influenza A only

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16
Q

PaRaMyxoviridae = pediatric illnesses

P.R.M.M

A

P. Parainfluenza
R. RSV
M. Measles
m. Mumps

17
Q

Infects the URT by droplet transmission then spreads via blood to RES and skin (maculopapular rash that starts on face)

A

Measles

18
Q

Bright red lesions with a white central dot on buccal mucosa

A

Koplik spots, measles

19
Q

Dawson Disease
Slow virus infection in the brain caused by defective measles virus leading to progressive, debilitating and deadly brain dso

A

SSPE

20
Q

Increased jaw pain when drinking citrus juices

A

Parotitis

21
Q

Negative sense enveloped RNA virus with no HA and NA, only fusion protein causing cells to aggregate

A

RSV

22
Q

DOC for RSV (and hepa C)

RRRSv CRRRR

A

Ribavir

23
Q

Inspiratory stridor, cough and hoarsenss

Steeple sign on Xray

A

LTB

Parainfluenza 1&2

24
Q

DOC for croup

A

Racemic epinephrine

25
Q

Bullet shaped enveloped virus with ss negative polarity RNA

A

Rabies virus

26
Q

Prominent club-shaped spikes
2nd MCC of common colds
Reservoir? Intermediate host?

A

Coronavirus
Res: horseshoe bat
IH: civet cat

27
Q

Atypical pneumonia rapidly progressing to ARDS

Virus binds to what receptor?

A

SARS

Virus binds to ACE-2 receptor

28
Q

DOC:
Acute hepa Ci
ChRRRonic hepa C

A

Interferon for acute

Ribavirin + peg interferon for chronic hepatitis

29
Q

Flaviviridae (2)

C.De.F.

A

Hepa C

Dengue

30
Q

Family of rubElla virus

A

Togaviridae

Naka Toga si Ella

31
Q

Maculopapular rash starting at the face, associated with posterior auricular LAD

A

Rubella

32
Q

5Bs of Congenital Rubella Syndrome

A 
Bulag (cataract)
Bingi (sensorineural)
Bobo (MR)
Butas ang puso (PDA)
Blueberry muffin baby
33
Q

Only RNA virus with reverse transcriptase

A

Retrovirus (reverse eh)
Aka RNA-dependent DNA polymerase
Sa DNA viruses - Hepadna

34
Q

Retrovirus causing adult T-cell leukemia and myelopathy

Flower-shaped nucleus

A

Human Tcell lymphotrophic Virus

35
Q

Longest and threadlike viruses causing hemorrhagic fever

A

Ebola virus (filoviridae)

Virology (4 decks)

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