RNA viruses

Question 1

All RNA viruses have SINGLE strand RNA except

Answer 1

Reovirus (rota)

Naked and with segments

Question 2

All RNA virus replicates in the cytoplasm, except 2

Nuclear IREa

Answer 2

Influenza

Retrovirus

Question 3

Picornaviridae

EnteroPico on a PERCH

Answer 3

P. Polio
E. Echo
R. Rhino
C. Coxsackie
H. HAV

Question 4

Poliovirus site of replication

Answer 4

Motor neurons in anterior horn of spinal cord, causing flaccid paralysis

Question 5

3 enteroviruses

Answer 5

Polio
Echo
Coxsackie

Question 6

1. Fever, sore throat and tender vesicles on posterior oropharynx
2. vesicles on mouth, hands, and feet

Answer 6

CMV

1. Herpangina -coxSUCKie
2. FMD - coxSACKie

Question 7

Only picornaviridae virus transmitted by droplet

Killed by gastric acid when swallowed

Answer 7

Rhinoviridae

Question 8

Aka enterovirus 72

Answer 8

Hepa A virus

Question 9

Family of Hepa E and Norwalk virus

Answer 9

Caliciviridae

Call don HeN

Question 10

Influenza envelope:

Binds to cell surface receptor to initiate infection

Answer 10

Hemagglutinins binds to

Neuraminic adic, sialic acid

Question 11

Influenza envelope:

Cleaves neuraminic acid (sialic acid) to release progency virus from infected cells

Answer 11

Neuraminidase

Also degrades protective mucus, enhancing access to RT

Question 12

Antigenic shift

Reassortment of HA and NA with animal strains

Answer 12

Influenza A = pandemics

Humans: H1-3, N1-2

Question 13

Antigenic drift (mutations)
No animal source of new RNA segment

Answer 13

Influenza B = epidemic

Question 14

Post-influenza complications (2)

Respi and autoimmune

Answer 14

Staph pneumonia

Reye’s syndrome if tx with aspirin

Question 15

DOC InfluenZa

TamA Zana

Answer 15

Oseltamivir (Tamiflu) and Zanamivir (neuraminidase inhibitors)
Amantadine inhibit replication of influenza A only

Question 16

PaRaMyxoviridae = pediatric illnesses

P.R.M.M

Answer 16

P. Parainfluenza
R. RSV
M. Measles
m. Mumps

Question 17

Infects the URT by droplet transmission then spreads via blood to RES and skin (maculopapular rash that starts on face)

Answer 17

Measles

Question 18

Bright red lesions with a white central dot on buccal mucosa

Answer 18

Koplik spots, measles

Question 19

Dawson Disease
Slow virus infection in the brain caused by defective measles virus leading to progressive, debilitating and deadly brain dso

Answer 19

SSPE

Question 20

Increased jaw pain when drinking citrus juices

Answer 20

Parotitis

Question 21

Negative sense enveloped RNA virus with no HA and NA, only fusion protein causing cells to aggregate

Answer 21

RSV

Question 22

DOC for RSV (and hepa C)

RRRSv CRRRR

Answer 22

Ribavir

Question 23

Inspiratory stridor, cough and hoarsenss

Steeple sign on Xray

Answer 23

LTB

Parainfluenza 1&2

Question 24

DOC for croup

Answer 24

Racemic epinephrine

Question 25

Bullet shaped enveloped virus with ss negative polarity RNA

Answer 25

Rabies virus

Question 26

Prominent club-shaped spikes 2nd MCC of common colds Reservoir? Intermediate host?

Answer 26

Coronavirus Res: horseshoe bat IH: civet cat

Question 27

Atypical pneumonia rapidly progressing to ARDS | Virus binds to what receptor?

Answer 27

SARS | Virus binds to ACE-2 receptor

Question 28

DOC: Acute hepa Ci ChRRRonic hepa C

Answer 28

Interferon for acute | Ribavirin + peg interferon for chronic hepatitis

Question 29

Flaviviridae (2) | C.De.F.

Answer 29

Hepa C | Dengue

Question 30

Family of rubElla virus

Answer 30

Togaviridae | Naka Toga si Ella

Question 31

Maculopapular rash starting at the face, associated with posterior auricular LAD

Answer 31

Rubella

Question 32

5Bs of Congenital Rubella Syndrome

Answer 32

``` Bulag (cataract) Bingi (sensorineural) Bobo (MR) Butas ang puso (PDA) Blueberry muffin baby ```

Question 33

Only RNA virus with reverse transcriptase

Answer 33

Retrovirus (reverse eh) Aka RNA-dependent DNA polymerase Sa DNA viruses - Hepadna

Question 34

Retrovirus causing adult T-cell leukemia and myelopathy | Flower-shaped nucleus

Answer 34

Human Tcell lymphotrophic Virus

Question 35

Longest and threadlike viruses causing hemorrhagic fever

Answer 35

Ebola virus (filoviridae)