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Virology > AIDS > Flashcards

AIDS Flashcards

1
Q

M.TB
HSV and candidal esophagitis
Kaposi sarcoma

A
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2
Q

PCP pneumonia

A
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3
Q

Cerebral toxoplasmosis

A
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4
Q

Meningoencephalitis

A
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5
Q

Coccidioidomycosis

A
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6
Q

Chronic diarrhea

A
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7
Q

Invasive pulmonary dse

A
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8
Q

Histoplasmosis

A
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9
Q

CMV retinitis

A
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10
Q

Presumptive test

A

ELISA

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11
Q

Definitive test

A

Western blot

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12
Q

Gold standa

A

PCR

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13
Q

Assessment of response to tx

A

Viral load

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14
Q

Treatment

A

HAART

2 nucleoside inhibitor (Zidovudine and lamivudine) and protease inhibitor (indinavir)

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15
Q 
Retrovirus structure
Surface protein
Transmembrane protein
Matrix protein
Major capsid protein
Nucleoprotein
A 
Surface - gp120, attachment protein
Transmembrane - gp41, Fusion protein
Matrix - MA, p17
capsid - CA, p24
NC, p7
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16
Q

directs entry of dsDNA provirus into the nucleus

A

MA, p17

17
Q

Retrovirus genes:
for nucleocapsid and matrix
for the enzymes
for invading proteins

A

p7, p24, p17 - gag
Enzymes - pol
gp41, gp120 - env

18
Q

Retrovirus enzymes

  • Transcribes RNA genome to DNA
  • Integrates viral DNA into host DNa
A

Reverse transcriptase

Integrase

19
Q

group specific antigen located at the core, not known to vary, however antibodies do not neutralize viral infectivity

A

p24

20
Q

Antigen located at the surface envelope which interacts with CD4 receptors; mutates rapidly, responsible for antigenic variants

A

gp120

Most immunogenic region: V3 loop

21
Q

Activation of transcription of viral genes

A

tat

sTArT

22
Q

Transport late mRNA to cytoplasm

A

rev

Revo transport

23
Q

Decreases CD4 and class I MHC proteins

A

nef

24
Q

Enhances hypermutation

A

vif

25
Q

Transport in nondividing cells

A

vpr

26
Q

Enhances virion release

A

vpu

Palabas

Virology (4 decks)

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