AIDS

Question 1

M.TB
HSV and candidal esophagitis
Kaposi sarcoma

Question 2

PCP pneumonia

Question 3

Cerebral toxoplasmosis

Question 4

Meningoencephalitis

Question 5

Coccidioidomycosis

Question 6

Chronic diarrhea

Question 7

Invasive pulmonary dse

Question 8

Histoplasmosis

Question 9

CMV retinitis

Question 10

Presumptive test

Answer 10

ELISA

Question 11

Definitive test

Answer 11

Western blot

Question 12

Gold standa

Answer 12

PCR

Question 13

Assessment of response to tx

Answer 13

Viral load

Question 14

Treatment

Answer 14

HAART

2 nucleoside inhibitor (Zidovudine and lamivudine) and protease inhibitor (indinavir)

Question 15

Retrovirus structure
Surface protein
Transmembrane protein
Matrix protein
Major capsid protein
Nucleoprotein

Answer 15

Surface - gp120, attachment protein
Transmembrane - gp41, Fusion protein
Matrix - MA, p17
capsid - CA, p24
NC, p7

Question 16

directs entry of dsDNA provirus into the nucleus

Answer 16

MA, p17

Question 17

Retrovirus genes:
for nucleocapsid and matrix
for the enzymes
for invading proteins

Answer 17

p7, p24, p17 - gag
Enzymes - pol
gp41, gp120 - env

Question 18

Retrovirus enzymes

• Transcribes RNA genome to DNA
• Integrates viral DNA into host DNa

Answer 18

Reverse transcriptase

Integrase

Question 19

group specific antigen located at the core, not known to vary, however antibodies do not neutralize viral infectivity

Answer 19

p24

Question 20

Antigen located at the surface envelope which interacts with CD4 receptors; mutates rapidly, responsible for antigenic variants

Answer 20

gp120

Most immunogenic region: V3 loop

Question 21

Activation of transcription of viral genes

Answer 21

tat

sTArT

Question 22

Transport late mRNA to cytoplasm

Answer 22

rev

Revo transport

Question 23

Decreases CD4 and class I MHC proteins

Answer 23

nef

Question 24

Enhances hypermutation

Answer 24

vif

Question 25

Transport in nondividing cells

Answer 25

vpr

Question 26

Enhances virion release

Answer 26

vpu Palabas