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Virology > DNA Viruses > Flashcards

DNA Viruses Flashcards

1
Q

DNA viruses are HHAPPPPy

A 
HepaDna - hepaB
Herpes (5)
Adeno - adenovirus
Pox - variola, vaccinia, molluscum
Polyoma
Papilloma (HPV)
Parvo - B19
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2
Q

All DNA viruses are double stranded EXCEPT

A

Parvo B-19

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3
Q

4 naked DNA viruses

3P.A.saway nakahubad

A

Papilloma
Polyoma
Parvo
Adeno

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4
Q

All DNA virus are icosahedral, except

A

Poxvirus (brick-shaped)

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5
Q

All DNA viruses have linear DNA, except 3 (PPH)

A

Polyoma, papilloma, Hepadna

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6
Q

All DNA viruses replicate in the nucleus except

A

Poxviridae
Largest viruses, hindi kasya sa nucleus
Replicates at cytoplasm

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7
Q

Erythema infectiosum
Bright red cheek rash
With fever and cough

A

Fifth disease

Parvovirus B19

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8
Q

Can trigger Aplastic crisis in sickle cell, thalassemia and spherocytosis patient

A

Parvovirus B19 infection

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9
Q

Infect squamous cells and induce formation of cytoplasmic vacoule (koilocytic change)

A

HPV

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10
Q

Oncogenic genes of HPV that encodes protein that inactivate tumor suppressor genes

A

Genes E6 & E7 of HPV

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11
Q

Causative strain:

  • Skin and plantar warts
  • Genital warts, RT papilloma
  • Carcinoma
A

1-4
6 and 11
16, 18, 31, 33

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12
Q

Treatment:
Skin warts
Genital warts
Plantar warts

A

Podophyllin
Liquid nitrogen
Salicylic acid

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13
Q

Causes demyelinating dse (affects oligodendocytes) in AIDS patients

A

JC Polyoma virus

Progressive multifocal leukoencephalopathy (PML)

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14
Q

Hemorrhagic cystitis and nephropathy in patients with solid organ (kidney) and bone marrow transplant

A

BK Polyoma Virus

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15
Q

Enveloped DNA viruses

H.awak H.awak P.ag apply

A

H. Hepadna
H. Herpes viridae
P. Poxviridae

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16
Q

Herpesviridae

May Herpes sya sa CHEVS nya

A 
C. CMV
H. HHV
E. EBV
V. VZV
S. Simplex
17
Q

Smear used for HSV

A

Tzanck smear

Tzanck heavens i dont have herpes!

18
Q

Lesion of HSV

A

Vesicles filled with virus particles and cell debris

19
Q

Viral sites of latency

  • HSV
  • VZV
A

HSV1: trigeminal ganglia
HSV2: lumbosacral ganglia
VZV: dorsal root ganglia

20
Q

TEMPORAL LOBE enceph vs. THALAMIC enceph

A

HSV1 vs Japanese enceph

21
Q

DOC for HSV and VZV

A

Acyclovir - shortens duration and reduce viral shedding

MOA: inhibit DNA synthesis

22
Q

Vesicular centrifugal (starts at trunk) rash with dewdrop on a rose petal appearance, but other lesions may appear on different stages

A

Varicella

23
Q

Painful vesicular rashes on the ear with ipsilateral facial paralysis due to involvement of geniculate ganglion

A

Ramsay Hunt Syndrome

Variant of zoster

24
Q

MC cause of infection in organ transplant patients
MC INFECTIOUS* cause of congenital abnormalities
MC cause of blindness in AIDS patients

A

CMV
Blue berry muffin baby
CMV Retinitis

25
Q

Culture media for CMV

A

Shell tubes

26
Q

Differential for mononucleosis

A

Heterophil neg - CMV

Heterophil positive - EBV (infectious mono)

27
Q

DOC for CMV

A

Gancyclovir because CMV is highly resistant to acyclovir

28
Q

Malignancies associated with EBV

A

Burkitt’s lymphoma
B-cell lymphoma
Nasopharyngeal ca in Chinese people
Hairy cell leukoplakia in AIDS px

29
Q

Associated with malignancy of vascular endothelial cells producing multiple dark purple, flat to nodular, skin lesions

A

HHV8

Kaposi sarcoma

30
Q

Papular skin lesion with umbilicated center
MOT?
DOC?

A

Molluscum contagiosum
Direct contact
Cifodovir

31
Q

Dane particle

A

Hepa B virus

32
Q

Only DNA virus that produces DNA by reverse transcription with mRNA as template

A

HBV

33
Q

Marker of HBV replication

A

HbeAg

Positive during incubation and active infection

34
Q

HBV-associated vasculitides

A

Polyarteritis nodosa

35
Q

Complication of HBV

Functional renal failure without renal pathology

A

Hepatorenal syndrome

36
Q

Complication of HBV

Pulmonary vascular dilation leads to overperfusion relative to ventilation

A

Hepatopulmonary syndrome

37
Q

DOC for Hepa B

A

Lamivudine and interferon alpha

Virology (4 decks)

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