DNA Viruses Flashcards
DNA viruses are HHAPPPPy
HepaDna - hepaB Herpes (5) Adeno - adenovirus Pox - variola, vaccinia, molluscum Polyoma Papilloma (HPV) Parvo - B19
All DNA viruses are double stranded EXCEPT
Parvo B-19
4 naked DNA viruses
3P.A.saway nakahubad
Papilloma
Polyoma
Parvo
Adeno
All DNA virus are icosahedral, except
Poxvirus (brick-shaped)
All DNA viruses have linear DNA, except 3 (PPH)
Polyoma, papilloma, Hepadna
All DNA viruses replicate in the nucleus except
Poxviridae
Largest viruses, hindi kasya sa nucleus
Replicates at cytoplasm
Erythema infectiosum
Bright red cheek rash
With fever and cough
Fifth disease
Parvovirus B19
Can trigger Aplastic crisis in sickle cell, thalassemia and spherocytosis patient
Parvovirus B19 infection
Infect squamous cells and induce formation of cytoplasmic vacoule (koilocytic change)
HPV
Oncogenic genes of HPV that encodes protein that inactivate tumor suppressor genes
Genes E6 & E7 of HPV
Causative strain:
- Skin and plantar warts
- Genital warts, RT papilloma
- Carcinoma
1-4
6 and 11
16, 18, 31, 33
Treatment:
Skin warts
Genital warts
Plantar warts
Podophyllin
Liquid nitrogen
Salicylic acid
Causes demyelinating dse (affects oligodendocytes) in AIDS patients
JC Polyoma virus
Progressive multifocal leukoencephalopathy (PML)
Hemorrhagic cystitis and nephropathy in patients with solid organ (kidney) and bone marrow transplant
BK Polyoma Virus
Enveloped DNA viruses
H.awak H.awak P.ag apply
H. Hepadna
H. Herpes viridae
P. Poxviridae
Herpesviridae
May Herpes sya sa CHEVS nya
C. CMV H. HHV E. EBV V. VZV S. Simplex
Smear used for HSV
Tzanck smear
Tzanck heavens i dont have herpes!
Lesion of HSV
Vesicles filled with virus particles and cell debris
Viral sites of latency
- HSV
- VZV
HSV1: trigeminal ganglia
HSV2: lumbosacral ganglia
VZV: dorsal root ganglia
TEMPORAL LOBE enceph vs. THALAMIC enceph
HSV1 vs Japanese enceph
DOC for HSV and VZV
Acyclovir - shortens duration and reduce viral shedding
MOA: inhibit DNA synthesis
Vesicular centrifugal (starts at trunk) rash with dewdrop on a rose petal appearance, but other lesions may appear on different stages
Varicella
Painful vesicular rashes on the ear with ipsilateral facial paralysis due to involvement of geniculate ganglion
Ramsay Hunt Syndrome
Variant of zoster
MC cause of infection in organ transplant patients
MC INFECTIOUS* cause of congenital abnormalities
MC cause of blindness in AIDS patients
CMV
Blue berry muffin baby
CMV Retinitis
