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I And I Final > RNA + Viruses > Flashcards

RNA + Viruses Flashcards

1
Q

Pico virus sketchy scene

A

Peak orna animal nursery

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2
Q

Naked, icosahedral, +ssDNA, small

A

Pico

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3
Q

All + sense get replicated

A

In cytoplasm

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4
Q

Polio transmission

A

Resp and fecal/oral

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5
Q

Polio can cross

A

BBB

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6
Q

Infects axons of peripheral nerves and attacks anterior horn of spinal cord

A

Polio

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7
Q

Most kids with _____ are asymptomatic

A

Polio

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8
Q

What percent of polio is severe

A

1-2

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9
Q

Paralysis of diaphragm

A

Polio

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10
Q

What are all the enteroviruses

A

Polio
Coxsackie
Echovirus
Enterovirus

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11
Q

Enteroviruses are stable at _____ pH

A

Acidic

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12
Q

Enteroviruses replicate in

A

Oropharynx and GI tract

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13
Q

Enterovirus 71 causes

A

Hand foot and mouth
Poliomyelitis
Not really in USA

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14
Q

Enterovirus D68 causes

A

Acute flaccid myelitis
a resp illness comes before this

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15
Q

Encephalomyocarditis syndrome

A

Coxsackie B1 virus

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16
Q

Acid labile +

A

Rhino

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17
Q

Major trigger of asthma exacerbations and development of childhood asthma

A

Rhino

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18
Q

How does hep A transmit

A

Contaminated food
Fecal oral - daycares
IV drug use - #1 in USA

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19
Q

Jaundice, abnormal liver enzymes, fever, fatigue, nausea, abdominal discomfort

A

Hep A

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20
Q

Leading cause of viral gastroenteritis over all age groups

A

Norovirus - caliciviridae

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21
Q

Food preparer who is no longer symptomatic can still transmit virus

A

Norovirus

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22
Q

Low infectious dose, naked, fecal/oral transmission, common in daycares

A

Norovirus

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23
Q

Enveloped, iscosahedaral, arbovirus

A

Flaviviridae

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24
Q

If you have an antibody for yellow fever what could you also be protected agains

A

Dengue
Yellow
Zika
WN
Japanese encephalitis
St. Louis encephalitis
Powassan

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25
Q

What are the primary targets for flaviviridae

A

Cells of monocyte and macrophage lineage
Also dendritic cells

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26
Q

May infect endothelial cells of capillaries, has glycoproteins E1 and E2

A

Flavivir

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27
Q

Breakbone fever

A

Dengue

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28
Q

Worldwide, especially tropics

A

Dengue

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29
Q

Africa, South America

A

Yellow fever

30
Q

Zika

A

Worldwide, especially tropics

31
Q

Asia

A

Japanese encephalitis

32
Q

Africa, Europe, Central Asia, North America

A

West nile

33
Q

North America

A

St. Louis encephalitis
And
Powassan encephalitis

34
Q

Sylvatic vs urban

A

S = wooded areas
primate —> mosquito—>human

U = human—>mosquito—>human

35
Q

Gets midgut of ____ and moves to their ____ glands

A

Mosquito

Salivary

36
Q

Arboviruses are picked up through the ___ but spread through ____

A

Blood

Saliva

37
Q

With arbovirus, if virus is not cleared after primary viremia what can happen

A

Secondary viremia can produce enough virus to infect other organs

38
Q

Mild affects of arbovirus primary viremia

A

Fever, chills, headaches, arthralgias

39
Q

Effects of secondary arbovirus viremia

A

Hemorrhagic feve
Shock
Encephalitis

40
Q

Assembly and release of HCV

A

HCV and VLDL form lipo viral particle

The viral antigens in LVP are shielded form immune response

41
Q

Flushed skin, red conjunctiva, hepatomegaly

A

YFV

42
Q

Yellow fever presentation

A

Infection—>remission—>intoxication—>death

43
Q

Intoxication YFV

A

High fever
Coagulopathy and hemorrhaging
Hepatic is wack/jaundice
Renal failure
Shock

44
Q

If you’re going to Africa or South America what should you get

A

YFV live vax

45
Q

Retro-orbital pain

A

Dengue

46
Q

Describe the antibody - dependent enhancement
Which disease

A

Dengue

1st infection: our body makes Ab to the infecting subtype

2nd infection: the 1Ab can cross react and bind to the 2nd infecting subtype. This enhances the uptake of the virus bc the virus has FC receptor

47
Q

Why can Zika be scary

A

Congenital Zika = microencephaly

Guillain barre

48
Q

Chronic inflammatory demyelinating polyneuropathy

A

Zika

49
Q

What are the encephalitis viruses

A

West Nile, St. Louis, Powassan

50
Q

Presentations of encephalitis viruses

A

Non-neuroinvasive

Neuroinvasive

51
Q

Intermediate host for MERS

A

Camels

52
Q

Largest RNA virus

A

Coronavirus

53
Q

What binds to ACE2

A

Spike protein

54
Q

Vax for sars cov2 induces antibodies to what

A

Spike protein

55
Q

MERS transmission

A

Person to person
Doesn’t spread well

56
Q

Which is more pathogenic SARSCOV or SARSCOV2

A

SARSCOV

57
Q

Why is SARSCOV2 more widespread and severe

A

Bc its less virulent so its harder to detect, people spread it easier

Mutates quick

58
Q

ARDS = ___
From what disease

A

Acute respiratory distress syndrome
Covid

59
Q

When do viral titers peak in covid

A

4 days after onset

60
Q

Describe Multisystem inflammatory syndrome what is it from

A

Cytokine storm like
heart, and kidney stuff
COVID

61
Q

SARS COV2 is huge so it has its own

A

Proofreading system

62
Q

Explain the variants of COV2

A

1: RNA polymerases make a lot of mistakes
2: recombination happens
3: this might change pathogenicity
4: which might make it easier to escape immune response
If we get OG variant our body makes Ab for OG. If we then get delta variant we do not already have the Ab for it

63
Q

Things in α genus of toga

A

EEEV
WEEV
VEEV
Chikungunya

64
Q

Toga altered pattern

A

+ RNA —> nonstructural proteins encoded in 5’ end of genomic RNA —-> - strand—-> subgenomic + mRNA from 3’ end——> structural proteins

65
Q

α virus that’s north & South America and Caribbean

A

EEEV

66
Q

α virus that’s North & South America

A

WEEV

67
Q

α virus that’s north, south and Central America

A

VEEV

68
Q

α virus that’s africa and Asia

A

Chikungunya

69
Q

Which α virus causes severe encephalitis

A

VEEV

70
Q

Severity of congenital rubella depends on

A

Fetal age at time of viremia

Major risk up until 20th week of pregnancy

I And I Final (5 decks)

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