Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

I And I Final > Major DNA Viruses > Flashcards

Major DNA Viruses Flashcards

1
Q

SsDNA naked, icosahedral

A

Parvovirus

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

Determinant for B19 tropism

A

Erythrocyte P antigen
acts as a receptor

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

____ a type of glycoshpingolipid on RBC

A

Globoside

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

When does parvovirus replicate

A

When host cell is in S phase

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

Why does B19 not attack RBC

A

Because they don’t have a nucleus
So they attach erythroblasts

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

B19 arthritis is from

A

Immune complex mediated

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

Most common age group fro 5th disease

A

5-14

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

Phases of erythema infectious

A

Phase 1 = infectious stage
Mild fever, sore throat, runny nose

Phase 2 = virus cleared
slapped cheek rash
lacy rash on trunk, arms, legs

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

Slapped cheek rash is ______

A

Immune complex mediated

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

B19 can cross

A

Placenta

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

B19 during 1st trimester =

A

Death

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

B19 during 2nd =

A

Hydrops fetalis —-> death

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

B19 during 3rd trimester

A

No apparent clinical symptoms

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

B19 treatment

A

No treatment unless immunocompromised
if so, maybe transfusion

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

Leading cause of pharyngitis

A

Adenovirus

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

Why does it make sense that adenovirus can have outbreaks in pools

A

It’s naked and can survive the chlorine in pools

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

Adenovirus types 4, 7, 14 are associated with

A

Severe lower resp tract infections

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
18
Q

Adenovirus types 40 + 41 associated with

A

Gastroenteritis; transmitted fecal/orally

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
19
Q

Adenovirus types 11 + 21 are associated with

A

Hemorrhagic cystitis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
20
Q

How would you diagnose adenovirus

A

Look for increase in antibody titer

PCR for viral sequences

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
21
Q

How do you treat adenovirus

A

Self resolves, you treat the symptoms

Live vax for military recruits

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
22
Q

________ for immunocomprimised people with severe adenovirus infection

A

Cidofovir

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
23
Q

Tropism for papilloma

A

Epithelial cells of skin and mucosa

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
24
Q

Papilloma is _____ infection on _____ cells

A

Lytic

Permissive

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
25
Q

Papilloma is _____ infecticions in ______

A

Transforming

Non permissive

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
26
Q

How do you transmit papilloma

A

Direct contact

Exposure during birth

Sex

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
27
Q

Papilloma route of transmission depends on

A

Serotype

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
28
Q

HPV infects _____ cells

A

Basal

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
29
Q

HPV, viral DNA induces cell proliferation and thickening in

A

Basal layer
Stratum spinous
Stratum granulosum

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
30
Q

HPV, mature virion is only on _____ layers of skin

A

Outermost

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
31
Q

How does HPV move on in association with skin

A

As our skin shed the viral particles get spread

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
32
Q

HPV latent vs transforming infections

A

L = viral DNA is not integrated

T = viral DNA is integrated

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
33
Q

E5 = ( of HPV)

A

Activates EGF, epithelial growth factor

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
34
Q

E6 =

A

Binds and targets p53 for degration

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
35
Q

E7 =

A

Binds and inactivates RB

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
36
Q

Verruca vulgaris

A

Common wart

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
37
Q

Where are verruca vulgaris usually

A

Hands and knees

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
38
Q

Verruca plana

A

Flat warts on hands, face, shins

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
39
Q

Plantar warts

A

Grow into soles of feet

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
40
Q

Condyloma acuminata aka

A

Genital warts

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
41
Q

Infected epithelial cells have a clear halo around a shrunken nucleus

A

Koilocytes

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
42
Q

Managing HPV

A

Could resolve spontaneously

Freeze

Surgically remove

Etc

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
43
Q

Preventing HPV

A

Vax!

Gardasil 9
covers 9 subtypes
6,11,16,18,31,33,45,52,58

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
44
Q

When should someone get gardasil

A

Before they’re sexually active

Starting at 11 years old

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
45
Q

___ cells express a capsid protein called ___

A

Yeast

L1

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
46
Q

Polyomaviridae is ____ in immunocompetent people

A

Asymptomatic

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
47
Q

Transmission of polyomavirus

A

Inhalation
Fecal/oral

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
48
Q

Kidneys are a big site of _____ with polyoma virus

A

Latency

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
49
Q

Latent infection of the kidneys =

A

BK

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
50
Q

Latent infection in kidneys, B cells, monocyte lineage cells

A

JC

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
51
Q

Why would polyoma get reactivated

A

Someone become immunocompromised

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
52
Q

Early genes of polyoma virus

A

T (transformation) antigens

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
53
Q

What do T antigens do

A

Bind and inactive p53 and retinoblastoma protein

54
Q

Late genes of polyoma virus

A

Capsid proteins
VP1
VP2
VP3

55
Q

VP1

A

Major capsid protein and viral attachment protein

56
Q

VP2 and VP3

A

Minor capsid proteins

57
Q

PML from

A

JC

58
Q

Hemorrhagic cystitis from

A

BK

Or adenovirus

59
Q

___ can cross bbb and replicates in the endothelial cells of ____

A

JC

Capillaries

60
Q

JC ____ infections of oligodendrocytes and astrocytes

A

Productive Lytic

61
Q

Subacute demyelinating disease

A

PML

62
Q

PML severity

A

> 90% fatality rate
2-4 months

63
Q

How do you diagnose polyoma

A

Urine cytologies tests

Detect gene seq in csf, pee, biopsy material

PML diagnosis

64
Q

What do you look for in a urine cytologies test for JC/BK

A

Enlarges cells with dense basophilic intranuclear inclusions consistent with JC/BK

65
Q

How do you diagnose PML

A

Histo of brain tissue = demyelination surrounded by oligodend. With inclusions

PCR detects viral DNA in csf

MRI showing lesions

66
Q

Adenovirus, papilloma, polyoma are all

A

Naked
dsDNA
Icosahedral

67
Q

Enveloped icosehedral

A

Herpes

68
Q

Alpha herpes primary target cell

What viruses

A

Epithelial cells

HSV1 - mucoepithelial cells, fibroblasts
HSV2 - mucoeptithelial cells, fibroblasts
VZV - mucoepithelial cells, T cells

69
Q

Beta viruses primary target cell

What viruses

A

Variety of cells

CMV - leukocytes, epithelial cells, fibroblasts
HHV6 - lymphocytes
HHV7 - lymphocytes

70
Q

Gamma viruses primary target cell

What viruses

A

EBV - B cells and epithelial cells

HSHV - B cells, endothelial cells, epithelial cells, monocytes

71
Q

Where do alpha sit latent

A

Neurons

72
Q

Where do gamma sit latent

A

B cells

73
Q

Where to beta sit latent

A

CMV - monocytes, myeloid stem cells
HHV6 - T cells
HHV7 - T cells

74
Q

Latency of HSV

A

Immediate early genes are NOT expressed so non of the early or late viral genes are expressed

75
Q

LATs are associated with

A

Replication of HSV

Latency-associated transcripts

76
Q

How does HSV mainly spread systemically

A

Traveling within infected leukocytes

VZV, EBV, CMV

77
Q

LATs inhibit _____ of infected neurons

A

Apoptosis

78
Q

LATs inhibit ____ of viral IE genes

A

Expression

79
Q

How is replication triggered in a _______ of HSV

A

Neuron

Sunlight
Fever
Stress
Immunosuppression

80
Q

What does deactivation look like in HSV

A

New viral particle travels down the axon to site of initial infection and productively infects epithelial cells

81
Q

What does reactivation look like in VZV

A

Reactivation = productive infection in a dermatome enervated by the neuron in which reactivation occurs

82
Q

HSV1, HSV2, VZV
Transmit by

A

Saliva
Sex
Hand to mouth
Skin to skin
wrestler, herpetic gladiatorum

83
Q

HSV and VZV lesions

A

Vesicles —> ulcer —> crusted lesions

84
Q

____ in the lesions contains infectious virus in alpha

A

Fluid

85
Q

HSV1 or 2 is more common of a genital infection

A

2

86
Q

Neonatal herpes usually caused by

A

HSV2

87
Q

Where does HSV reactivate vs VZV

A

H = cold sores, genital lesions

V = Zosters

88
Q

Where does HSV reactivate vs VZV

A

H: site of primary infection

V: Site where virus entered neuron

89
Q

How often does HSV vs VZV reactivate

A

H: often

V: 1 episode

90
Q

probability of reactivation of HSV vs VZV

A

H: decreases with age

V: increases with age

91
Q

What do you look for in a tzanck smear

A

Syncytia

Cow dry type A intranuclear inclusion bodies

92
Q

Serology of HSV vs VZV

A

H: significant increase in titer may not occur in reactivation

V: antibody tigers do increase in pt with zoster

93
Q

Prego mamas avoid HSV and VZV by

A

C section

94
Q

A kid immunocomprimised doesn’t get VZV vax instead ___ because

A

They get anti-VZV immunoglobulin

Vax could cause the disease

95
Q

What is more likely to cause roseola

A

HHV6

96
Q

How do you differentiate CMV and EBV

A

Heterophile antibody negative mononucleosis

97
Q

CMV is ____ severe than EBV mono

A

Less

98
Q

Which mono is it rare to see exudative pharyngitis, CMV or EBV

A

CMV

99
Q

How can cytomegalic inclusion disease be reactivated

A

During pregnancy
Mom has protective antibodies and a healthy newborn BUT there is a prolonged shedding of virus

100
Q

EBV receptor

A

CR2/CD21

this is a receptor for 		C3b
101
Q

With EBV what is used as a co-receptor

A

MHC class II

102
Q

Productive infection of EBV proteins

A

VCA - viral capsid antigen
EA - early antigen
MA - membrane antigen
Zebra - transcription activator; activates immediate early genes

103
Q

Non productiveinfection of EBV proteins

A

EBNAs - Epsetin Barr nuclear antigens
LP - Latent proteins
LMP 1 & 2 - Latent membrane proteins
EBER 1 & 2 - 2 small ep. Barr encoded rna molecules

104
Q

What indicates previous infection of EBV

A

Detecting both VCA IgG & EBNA antibodies

105
Q

See infectious mononucleosis pic

A

Yub yub

106
Q

Primary infection of HHV8 in immunocompetent ppl

A

Asymptomatic

107
Q

Primary infection of HHV8 in immunocomprimised ppl

A

Fever, spleen omega lay, lymphoid hyperplasia

108
Q

Transformation of HHV8

A

Virus expresses proteins with homologous to cellular proteins that promote growth + inhibit apoptosis

109
Q

Kaposi sarcoma characteristics

A

Cancer of lymph endothelial lining

Bluish red cutaneous nodules

110
Q

Primary effusion lymphoma aka

A

Body cavity based lymphomas

111
Q

Multi centric castleman’s disease is what and what is it associated with

A

lymphoproliferative disease

Fever, splenomegaly, hepatomegaly, generalized lymphadenopathy

HHV8

112
Q

HBsAG =

A

Hepatitis B surface Antigen

113
Q

If you have an antibody to HBsAG =

A

You have immunity to HBV

114
Q

HBV is a ____ virus that replicates through an _____

A

DNA

RNA intermediary

115
Q

P protein of HBV is what

A

RNA dependent DNA polymerase with RNase H activity

116
Q

Gene S of HBV

A

Surface glycoprotein (HBsAg)

Small medium and large

117
Q

Gene C of HBV

A

2 Initiation codons
HBcAg = core protein
HBeAG= secreted protein

118
Q

What is a marker for high infectivity of HBV

A

HBeAG

119
Q

How is HBV transmitted

A

Sexual, IV drug use, blood, perinatal

120
Q

Acute infection of HBV signs

A

Incubates 6 weeks to 6 months

Fever, fatigue, nausea, ab discomfort, DARK URINE, JAUNDICE

Lasts 1-3 weeks

121
Q

Chronic hepatitis infections signs

A

HBsAG for more than 6 months

Anti HBC = positive
Anthi HBs = negative

122
Q

Prevent HBV with

A

Vax

123
Q

Managing HBV with

A

HBV immunoglobulin after exposure

Antiviral drugs
that inhibit rna dependent DNA polymerase

124
Q

Small pox aka

A

Variola

125
Q

Monkey pox and variable name

A

Orthopoxvirus

126
Q

Smallpox vax is

A

Live attenuated

127
Q

How do you transmit monkey pox

A

Contact with fluid from lesions

128
Q

Symptoms of monkey pox

A

Like small pox but milder

Flu-like symptoms
Lymphadenopathy
Rash

129
Q

Umbilicated lesion =

A

Molluscom contagiosum

130
Q

Molluscum vs chicken pox

A

M = harder papule than fluid filled chicken pox

M= last for weeks

Chicken = clears up in weeks

I And I Final (5 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions