RLS

Question 1

RLS OF Glycolysis converts glucose C6H12O6, into pyruvate

Answer 1

Phosphofructokinase - 1 (PFK-1) In Cytosol

Question 2

RLS OF Gluconeogenesis

Answer 2

Fructose-1,6 bisphosphatase In Cytosol

Question 3

RLS OF TCA cycle

Answer 3

Isocitrate Dehydrogenase

Question 4

RLS OF Glycogen Synthesis

Answer 4

Glycogen Synthase

Question 5

RLS OF Glycogenolysis

Answer 5

Glyogen Phosphorylase

*Deficient in McArle’s Disease

Question 6

RLS OF HMP Shunt

Answer 6

Glucose-6-phosphate dehydrogenase (G6PD)

Question 7

RLS OF De Novo Pyrimidine Synthesis

Answer 7

Carbamoyl Phosphate Synthase II (CPS II)

*done in cytosol

Question 8

RLS OF De Novo Purine Synthesis

Answer 8

Glutamine- PRPP Amidotransferase

Question 9

RLS OF Urea Cycle

Answer 9

Carbamoyl Phosphate Synthase I (CPS I)

*done in mitochondria

Question 10

RLS OF Fatty Acid Synthesis

Answer 10

Acetyl-CoA Carboxylase (ACC)

Question 11

RLS OF Fatty Acid Oxidation

Answer 11

Carnitine Acetyltransferase I

Question 12

RLS OF Ketogenesis

Answer 12

HMG-CoA Synthase

Question 13

RLS OF Cholesterol Synthesis

Answer 13

HMG-CoA Reductase

Question 14

Pyruvate converted to Oxaloacetate by?

Answer 14

Pyruvate carboxylase Need Biotin,ATP, and CO2;

Activated by acetyl-CoA

*mitochondria

Question 15

Oxaloacetate converted to Phosphoenolpyruvate (PEP) by?

Answer 15

Phosphoenolpyruvate (PEP) Carboxykinase (in Cytosol);

Requires GTP

Question 16

Ethanol to Acetaldehyde

Answer 16

Alcohol dehydrogenase *inhibited by Fomepizole;

Ethanol to Acetaldehyde = NAD to NADH In the Cytosol

Question 17

Acetaldehyde to Acetate

Answer 17

Acetaldehyde Dehydrogenase
*inhibited by Disulfram/Antibuse;

(mitochondria) NADH increased

Question 18

Fructose to Fructose 1P

Answer 18

Fructokinase Using ATP to ADP

*Deficiency is Essential Frucotosuria

Question 19

Fructose 1p converted to Dihydroxyacetone and Glyceraldehyde by________ which converted to Glyceraldehyde 3-P

Answer 19

Aldolase B

*Deficiency is Fructose intolerance

Question 20

Galactose goes to Galactitol

Answer 20

Aldose reductase

Question 21

Galactose goes to Galactose 1P

Answer 21

Galactokinase Using ATP to ADP

*Deficiency is Galactokinase deficiency

Question 22

Galactose 1-P goes to Glucose 1-p

Answer 22

Galactose 1 Phosphate Uridyl Transferase Using UDP-Glu to UDP-Gal (Severe galactosemia)

Question 23

RLS of Heme Synthesis

Answer 23

Aminolevulinic Acid Synthase

Question 24

RLS of Bile Acid Synthesis

Answer 24

7-Alpha hydroxylase

Question 25

Glucose 6-phosphate to Glucose

Answer 25

Glucose 6 Phosphatase

Question 26

Glucose to Glucose 6 Phosphate

Answer 26

Hexokinase / Glucokinase

Question 27

Pyruvate goes to Acetyl-Coa

Answer 27

Pyruvate dehydrogenase

Question 28

Phosphoenolypyruvate goes to Pyruvate in Glycolysis

Answer 28

Pyruvate Kinase